Immuno gold nanocages with tailored optical properties for targeted photothermal destruction of cancer cells

Jingyi Chen, Danling Wang, Jiefeng Xi, Leslie Au, Andy Siekkinen, Addie Warsen, Zhi Yuan Li, Hui Zhang, Younan Xia, Xingde Li

Research output: Contribution to journalArticle

Abstract

Gold nanocages with a relatively small size (e.g., ∼45 nm in edge length) have been developed, and the structure of these nanocages was tailored to achieve strong absorption in the near-infrared (NIR) region for photothermal cancer treatment. Numerical calculations show that the nanocage has a large absorption cross section of 3.48 × 10-14 m2, facilitating conversion of NIR irradiation into heat. The gold nanocages were conjugated with monoclonal antibodies (anti-HER2) to target epidermal growth factor receptors (EGFR) that are overexpressed on the surface of breast cancer cells (SK-BR-3). Our preliminary photothermal results show that the nanocages strongly absorb light in the NIR region with an intensity threshold of 1.5 W/cm2 to induce thermal destruction to the cancer cells. In the intensity range of 1.5-4.7 W/cm2, the circular area of damaged cells increased linearly with the irradiation power density. These results suggest that this new class of bioconjugated gold nanostructures, immuno gold nanocages, can potentially serve as an effective photothermal therapeutic agent for cancer treatment.

Original languageEnglish (US)
Pages (from-to)1318-1322
Number of pages5
JournalNano Letters
Volume7
Issue number5
DOIs
StatePublished - May 2007

Fingerprint

Gold
destruction
Optical properties
cancer
Cells
gold
optical properties
Oncology
Infrared radiation
Irradiation
irradiation
Monoclonal antibodies
antibodies
breast
absorption cross sections
radiant flux density
Nanostructures
Monoclonal Antibodies
heat
thresholds

ASJC Scopus subject areas

  • Materials Science(all)
  • Electronic, Optical and Magnetic Materials
  • Chemistry (miscellaneous)

Cite this

Immuno gold nanocages with tailored optical properties for targeted photothermal destruction of cancer cells. / Chen, Jingyi; Wang, Danling; Xi, Jiefeng; Au, Leslie; Siekkinen, Andy; Warsen, Addie; Li, Zhi Yuan; Zhang, Hui; Xia, Younan; Li, Xingde.

In: Nano Letters, Vol. 7, No. 5, 05.2007, p. 1318-1322.

Research output: Contribution to journalArticle

Chen, J, Wang, D, Xi, J, Au, L, Siekkinen, A, Warsen, A, Li, ZY, Zhang, H, Xia, Y & Li, X 2007, 'Immuno gold nanocages with tailored optical properties for targeted photothermal destruction of cancer cells', Nano Letters, vol. 7, no. 5, pp. 1318-1322. https://doi.org/10.1021/nl070345g
Chen, Jingyi ; Wang, Danling ; Xi, Jiefeng ; Au, Leslie ; Siekkinen, Andy ; Warsen, Addie ; Li, Zhi Yuan ; Zhang, Hui ; Xia, Younan ; Li, Xingde. / Immuno gold nanocages with tailored optical properties for targeted photothermal destruction of cancer cells. In: Nano Letters. 2007 ; Vol. 7, No. 5. pp. 1318-1322.
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