Immunization-safety monitoring systems for the 2009 H1N1 monovalent influenza vaccination program

Daniel Salmon, Aysha Akhtar, Michelle J. Mergler, Kirsten S. Vannice, Hector Izurieta, Robert Ball, Grace M. Lee, Claudia Vellozzi, Patrick Garman, Francesca Cunningham, Bruce Gellin, Howard Koh, Nicole Lurie, Dale R. Burwen, Jay C. Butler, Vito Caserta, George Curlin, Frank DeStefano, Arthur Elliot, Amy V. GroomHayley Hughes, Rita Helfand, Wei Hua, Jeffrey Kelman, George Korch, Philip R. Krause, Sarah Landry, Karen Midthun, Yandong Qiang, John T. Redd, Elizabeth L. Skillen, Andrea R. Sutherland, Cindy Weinbaum, Robert P. Wise

Research output: Contribution to journalArticle

Abstract

The effort to vaccinate the US population against the 2009 H1N1 influenza virus hinged, in part, on public confidence in vaccine safety. Early in the vaccine program, >20% of parents reported that they would not vaccinate their children. Concerns about the safety of the vaccines were reported by many parents as a factor that contributed to their intention to forgo vaccination (see www.hsph.harvard.edu/news/ press-releases/2009-releases/survey-40-adults- absolutely-certain-h1n1-vaccine.html and www.med.umich.edu/mott/npch/reports/ h1n1.htm). The safety profiles of 2009 H1N1 monovalent influenza vaccines were anticipated to be (and have been) similar to those of seasonal influenza vaccines, for which an excellent safety profile has been demonstrated. Here we describe steps taken by the US government to (1) assess the key federal systems in place before 2009 for monitoring the safety of vaccines and (2) integrate and upgrade those systems for optimal vaccine-safety monitoring during the 2009 H1N1 monovalent influenza vaccination program. These efforts improved monitoring of 2009 H1N1 vaccine safety, hold promise for enhancing future national monitoring of vaccine safety, and may ultimately help improve public confidence in vaccines.

Original languageEnglish (US)
JournalPediatrics
Volume127
Issue numberSUPPL. 1
DOIs
StatePublished - May 2011
Externally publishedYes

Fingerprint

Human Influenza
Immunization
Vaccination
Vaccines
Safety
Influenza Vaccines
Parents
H1N1 Subtype Influenza A Virus
Orthomyxoviridae
Population

Keywords

  • H1N1 influenza
  • Vaccine safety

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Salmon, D., Akhtar, A., Mergler, M. J., Vannice, K. S., Izurieta, H., Ball, R., ... Wise, R. P. (2011). Immunization-safety monitoring systems for the 2009 H1N1 monovalent influenza vaccination program. Pediatrics, 127(SUPPL. 1). https://doi.org/10.1542/peds.2010-1722L

Immunization-safety monitoring systems for the 2009 H1N1 monovalent influenza vaccination program. / Salmon, Daniel; Akhtar, Aysha; Mergler, Michelle J.; Vannice, Kirsten S.; Izurieta, Hector; Ball, Robert; Lee, Grace M.; Vellozzi, Claudia; Garman, Patrick; Cunningham, Francesca; Gellin, Bruce; Koh, Howard; Lurie, Nicole; Burwen, Dale R.; Butler, Jay C.; Caserta, Vito; Curlin, George; DeStefano, Frank; Elliot, Arthur; Groom, Amy V.; Hughes, Hayley; Helfand, Rita; Hua, Wei; Kelman, Jeffrey; Korch, George; Krause, Philip R.; Landry, Sarah; Midthun, Karen; Qiang, Yandong; Redd, John T.; Skillen, Elizabeth L.; Sutherland, Andrea R.; Weinbaum, Cindy; Wise, Robert P.

In: Pediatrics, Vol. 127, No. SUPPL. 1, 05.2011.

Research output: Contribution to journalArticle

Salmon, D, Akhtar, A, Mergler, MJ, Vannice, KS, Izurieta, H, Ball, R, Lee, GM, Vellozzi, C, Garman, P, Cunningham, F, Gellin, B, Koh, H, Lurie, N, Burwen, DR, Butler, JC, Caserta, V, Curlin, G, DeStefano, F, Elliot, A, Groom, AV, Hughes, H, Helfand, R, Hua, W, Kelman, J, Korch, G, Krause, PR, Landry, S, Midthun, K, Qiang, Y, Redd, JT, Skillen, EL, Sutherland, AR, Weinbaum, C & Wise, RP 2011, 'Immunization-safety monitoring systems for the 2009 H1N1 monovalent influenza vaccination program', Pediatrics, vol. 127, no. SUPPL. 1. https://doi.org/10.1542/peds.2010-1722L
Salmon, Daniel ; Akhtar, Aysha ; Mergler, Michelle J. ; Vannice, Kirsten S. ; Izurieta, Hector ; Ball, Robert ; Lee, Grace M. ; Vellozzi, Claudia ; Garman, Patrick ; Cunningham, Francesca ; Gellin, Bruce ; Koh, Howard ; Lurie, Nicole ; Burwen, Dale R. ; Butler, Jay C. ; Caserta, Vito ; Curlin, George ; DeStefano, Frank ; Elliot, Arthur ; Groom, Amy V. ; Hughes, Hayley ; Helfand, Rita ; Hua, Wei ; Kelman, Jeffrey ; Korch, George ; Krause, Philip R. ; Landry, Sarah ; Midthun, Karen ; Qiang, Yandong ; Redd, John T. ; Skillen, Elizabeth L. ; Sutherland, Andrea R. ; Weinbaum, Cindy ; Wise, Robert P. / Immunization-safety monitoring systems for the 2009 H1N1 monovalent influenza vaccination program. In: Pediatrics. 2011 ; Vol. 127, No. SUPPL. 1.
@article{d5fb3b4bfb4c42659cdedc59a4843c07,
title = "Immunization-safety monitoring systems for the 2009 H1N1 monovalent influenza vaccination program",
abstract = "The effort to vaccinate the US population against the 2009 H1N1 influenza virus hinged, in part, on public confidence in vaccine safety. Early in the vaccine program, >20{\%} of parents reported that they would not vaccinate their children. Concerns about the safety of the vaccines were reported by many parents as a factor that contributed to their intention to forgo vaccination (see www.hsph.harvard.edu/news/ press-releases/2009-releases/survey-40-adults- absolutely-certain-h1n1-vaccine.html and www.med.umich.edu/mott/npch/reports/ h1n1.htm). The safety profiles of 2009 H1N1 monovalent influenza vaccines were anticipated to be (and have been) similar to those of seasonal influenza vaccines, for which an excellent safety profile has been demonstrated. Here we describe steps taken by the US government to (1) assess the key federal systems in place before 2009 for monitoring the safety of vaccines and (2) integrate and upgrade those systems for optimal vaccine-safety monitoring during the 2009 H1N1 monovalent influenza vaccination program. These efforts improved monitoring of 2009 H1N1 vaccine safety, hold promise for enhancing future national monitoring of vaccine safety, and may ultimately help improve public confidence in vaccines.",
keywords = "H1N1 influenza, Vaccine safety",
author = "Daniel Salmon and Aysha Akhtar and Mergler, {Michelle J.} and Vannice, {Kirsten S.} and Hector Izurieta and Robert Ball and Lee, {Grace M.} and Claudia Vellozzi and Patrick Garman and Francesca Cunningham and Bruce Gellin and Howard Koh and Nicole Lurie and Burwen, {Dale R.} and Butler, {Jay C.} and Vito Caserta and George Curlin and Frank DeStefano and Arthur Elliot and Groom, {Amy V.} and Hayley Hughes and Rita Helfand and Wei Hua and Jeffrey Kelman and George Korch and Krause, {Philip R.} and Sarah Landry and Karen Midthun and Yandong Qiang and Redd, {John T.} and Skillen, {Elizabeth L.} and Sutherland, {Andrea R.} and Cindy Weinbaum and Wise, {Robert P.}",
year = "2011",
month = "5",
doi = "10.1542/peds.2010-1722L",
language = "English (US)",
volume = "127",
journal = "Pediatrics",
issn = "0031-4005",
publisher = "American Academy of Pediatrics",
number = "SUPPL. 1",

}

TY - JOUR

T1 - Immunization-safety monitoring systems for the 2009 H1N1 monovalent influenza vaccination program

AU - Salmon, Daniel

AU - Akhtar, Aysha

AU - Mergler, Michelle J.

AU - Vannice, Kirsten S.

AU - Izurieta, Hector

AU - Ball, Robert

AU - Lee, Grace M.

AU - Vellozzi, Claudia

AU - Garman, Patrick

AU - Cunningham, Francesca

AU - Gellin, Bruce

AU - Koh, Howard

AU - Lurie, Nicole

AU - Burwen, Dale R.

AU - Butler, Jay C.

AU - Caserta, Vito

AU - Curlin, George

AU - DeStefano, Frank

AU - Elliot, Arthur

AU - Groom, Amy V.

AU - Hughes, Hayley

AU - Helfand, Rita

AU - Hua, Wei

AU - Kelman, Jeffrey

AU - Korch, George

AU - Krause, Philip R.

AU - Landry, Sarah

AU - Midthun, Karen

AU - Qiang, Yandong

AU - Redd, John T.

AU - Skillen, Elizabeth L.

AU - Sutherland, Andrea R.

AU - Weinbaum, Cindy

AU - Wise, Robert P.

PY - 2011/5

Y1 - 2011/5

N2 - The effort to vaccinate the US population against the 2009 H1N1 influenza virus hinged, in part, on public confidence in vaccine safety. Early in the vaccine program, >20% of parents reported that they would not vaccinate their children. Concerns about the safety of the vaccines were reported by many parents as a factor that contributed to their intention to forgo vaccination (see www.hsph.harvard.edu/news/ press-releases/2009-releases/survey-40-adults- absolutely-certain-h1n1-vaccine.html and www.med.umich.edu/mott/npch/reports/ h1n1.htm). The safety profiles of 2009 H1N1 monovalent influenza vaccines were anticipated to be (and have been) similar to those of seasonal influenza vaccines, for which an excellent safety profile has been demonstrated. Here we describe steps taken by the US government to (1) assess the key federal systems in place before 2009 for monitoring the safety of vaccines and (2) integrate and upgrade those systems for optimal vaccine-safety monitoring during the 2009 H1N1 monovalent influenza vaccination program. These efforts improved monitoring of 2009 H1N1 vaccine safety, hold promise for enhancing future national monitoring of vaccine safety, and may ultimately help improve public confidence in vaccines.

AB - The effort to vaccinate the US population against the 2009 H1N1 influenza virus hinged, in part, on public confidence in vaccine safety. Early in the vaccine program, >20% of parents reported that they would not vaccinate their children. Concerns about the safety of the vaccines were reported by many parents as a factor that contributed to their intention to forgo vaccination (see www.hsph.harvard.edu/news/ press-releases/2009-releases/survey-40-adults- absolutely-certain-h1n1-vaccine.html and www.med.umich.edu/mott/npch/reports/ h1n1.htm). The safety profiles of 2009 H1N1 monovalent influenza vaccines were anticipated to be (and have been) similar to those of seasonal influenza vaccines, for which an excellent safety profile has been demonstrated. Here we describe steps taken by the US government to (1) assess the key federal systems in place before 2009 for monitoring the safety of vaccines and (2) integrate and upgrade those systems for optimal vaccine-safety monitoring during the 2009 H1N1 monovalent influenza vaccination program. These efforts improved monitoring of 2009 H1N1 vaccine safety, hold promise for enhancing future national monitoring of vaccine safety, and may ultimately help improve public confidence in vaccines.

KW - H1N1 influenza

KW - Vaccine safety

UR - http://www.scopus.com/inward/record.url?scp=79955486652&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955486652&partnerID=8YFLogxK

U2 - 10.1542/peds.2010-1722L

DO - 10.1542/peds.2010-1722L

M3 - Article

C2 - 21502251

AN - SCOPUS:79955486652

VL - 127

JO - Pediatrics

JF - Pediatrics

SN - 0031-4005

IS - SUPPL. 1

ER -