Immunization for Ebola virus infection

Ling Xu, Anthony Sanchez, Zhi Yong Yang, Sherif R. Zaki, Elizabeth G. Nabel, Stuart T. Nichol, Gary J. Nabel

Research output: Contribution to journalArticle

Abstract

Infection by Ebola virus causes rapidly progressive, often fatal, symptoms of fever, hemorrhage and hypotension. Previous attempts to elicit protective immunity for this disease have not met with success. We report here that protection against the lethal effects of Ebola virus can be achieved in an animal model by immunizing with plasmids encoding viral proteins. We analyzed immune responses to the viral nucleoprotein (NP) and the secreted or transmembrane forms of the glycoprotein (sGP or GP) and their ability to protect against infection in a guinea pig infection model analogous to the human disease. Protection was achieved and correlated with antibody titer and antigen-specific T-cell responses to sGP or GP. Immunity to Ebola virus can therefore be developed through genetic vaccination and may facilitate efforts to limit the spread of this disease.

Original languageEnglish (US)
Pages (from-to)37-42
Number of pages6
JournalNature Medicine
Volume4
Issue number1
DOIs
StatePublished - 1998
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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  • Cite this

    Xu, L., Sanchez, A., Yang, Z. Y., Zaki, S. R., Nabel, E. G., Nichol, S. T., & Nabel, G. J. (1998). Immunization for Ebola virus infection. Nature Medicine, 4(1), 37-42. https://doi.org/10.1038/nm0198-037