TY - JOUR
T1 - Immunization against tularemia
T2 - analysis of the effectiveness of live Francisella tularensis vaccine in prevention of laboratory acquired tularemia
AU - D.S.,
PY - 1977/1/1
Y1 - 1977/1/1
N2 - A retrospective analysis was made of cases of laboratory acquired infections with Francisella tularensis among civilian employees at Fort Detrick, Maryland. The incidence and clinical presentation of tularemia during the decade 1950-1959, when the phenol killed Foshay vaccine was used routinely for immunization of employees, were compared with similar data from the first decade (1960-1969) after the live tularemia vaccine had come into use. The incidence of typhoidal tularemia fell (from 5.70 to 0.27 cases per 1,000 at risk employee years; P<0.001), whereas the incidence of ulceroglandular tularemia remained unchanged (from 0.76 to 0.54 cases per 1,000 at risk employee years). Ulceroglandular tularemia in employees immunized with live vaccine was characterized by clinical signs and symptoms that were milder than those in employees vaccinated with the Foshay vaccine.
AB - A retrospective analysis was made of cases of laboratory acquired infections with Francisella tularensis among civilian employees at Fort Detrick, Maryland. The incidence and clinical presentation of tularemia during the decade 1950-1959, when the phenol killed Foshay vaccine was used routinely for immunization of employees, were compared with similar data from the first decade (1960-1969) after the live tularemia vaccine had come into use. The incidence of typhoidal tularemia fell (from 5.70 to 0.27 cases per 1,000 at risk employee years; P<0.001), whereas the incidence of ulceroglandular tularemia remained unchanged (from 0.76 to 0.54 cases per 1,000 at risk employee years). Ulceroglandular tularemia in employees immunized with live vaccine was characterized by clinical signs and symptoms that were milder than those in employees vaccinated with the Foshay vaccine.
UR - http://www.scopus.com/inward/record.url?scp=0017361312&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017361312&partnerID=8YFLogxK
M3 - Article
C2 - 833449
AN - SCOPUS:0017361312
SN - 0022-1899
VL - 135
SP - 55
EP - 60
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 1
ER -