Immunity to Plasmodium sporozoites: recent advances and applications to field research.

F. Esposito, S. Lombardi, D. Modiano, Fidel P Zavala, J. Reeme, L. Lamizana, M. Coluzzi, R. S. Nussenzweig

Research output: Contribution to journalArticle

Abstract

The presence of antibodies against Plasmodium falciparum sporozoites in humans living in malaria endemic areas was measured using as antigen the synthetic peptide (NANP)3, which represents the immunodominant region of the circumsporozoite (CS) protein. The results indicate that: i) the production of anti-CS antibodies is unrelated to the presence in the circulation of blood-stage parasites; ii) anti-CS antibodies, raised by natural inoculation, could exert a protective role against natural malaria infection; iii) anti-CS antibodies can be used as indicators of the intensity of malaria transmission.

Original languageEnglish (US)
Pages (from-to)101-105
Number of pages5
JournalParassitologia
Volume28
Issue number2-3
StatePublished - Aug 1986
Externally publishedYes

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Sporozoites
Plasmodium
Malaria
Anti-Idiotypic Antibodies
Immunity
Research
Immunodominant Epitopes
Synthetic Vaccines
Blood Circulation
Plasmodium falciparum
Parasites
Peptides
Antibodies
Infection
Proteins

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

Cite this

Esposito, F., Lombardi, S., Modiano, D., Zavala, F. P., Reeme, J., Lamizana, L., ... Nussenzweig, R. S. (1986). Immunity to Plasmodium sporozoites: recent advances and applications to field research. Parassitologia, 28(2-3), 101-105.

Immunity to Plasmodium sporozoites : recent advances and applications to field research. / Esposito, F.; Lombardi, S.; Modiano, D.; Zavala, Fidel P; Reeme, J.; Lamizana, L.; Coluzzi, M.; Nussenzweig, R. S.

In: Parassitologia, Vol. 28, No. 2-3, 08.1986, p. 101-105.

Research output: Contribution to journalArticle

Esposito, F, Lombardi, S, Modiano, D, Zavala, FP, Reeme, J, Lamizana, L, Coluzzi, M & Nussenzweig, RS 1986, 'Immunity to Plasmodium sporozoites: recent advances and applications to field research.', Parassitologia, vol. 28, no. 2-3, pp. 101-105.
Esposito F, Lombardi S, Modiano D, Zavala FP, Reeme J, Lamizana L et al. Immunity to Plasmodium sporozoites: recent advances and applications to field research. Parassitologia. 1986 Aug;28(2-3):101-105.
Esposito, F. ; Lombardi, S. ; Modiano, D. ; Zavala, Fidel P ; Reeme, J. ; Lamizana, L. ; Coluzzi, M. ; Nussenzweig, R. S. / Immunity to Plasmodium sporozoites : recent advances and applications to field research. In: Parassitologia. 1986 ; Vol. 28, No. 2-3. pp. 101-105.
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