Immunity-related genes and gene families in Anopheles gambiae

George K. Christophides, Evgeny Zdobnov, Carolina Barillas-Mury, Ewan Birney, Stephanie Blandin, Claudia Blass, Paul T. Brey, Frank H. Collins, Alberto Danielli, George Dimopoulos, Charles Hetru, Ngo T. Hoa, Jules A. Hoffmann, Stefan M. Kanzok, Ivica Letunic, Elena A. Levashina, Thanasis G. Loukeris, Gareth Lycett, Stephan Meister, Kristin MichelLuis F. Moita, Hans Michael Müller, Mike A. Osta, Susan M. Paskewitz, Jean Marc Reichhart, Andrey Rzhetsky, Laurent Troxler, Kenneth D. Vernick, Dina Vlachou, Jennifer Volz, Christian Von Mering, Jiannong Xu, Liangbiao Zheng, Peer Bork, Fotis C. Kafatos

Research output: Contribution to journalArticle

Abstract

We have identified 242 Anopheles gambiae genes from 18 gene families implicated in innate immunity and have detected marked diversification relative to Drosophila melanogaster. Immune-related gene families involved in recognition, signal modulation, and effector systems show a marked deficit of orthologs and excessive gene expansions, possibly reflecting selection pressures from different pathogens encountered in these insects' very different life-styles. In contrast, the multifunctional Toll signal transduction pathway is substantially conserved, presumably because of counterselection for developmental stability. Representative expression profiles confirm that sequence diversification is accompanied by specific responses to different immune challenges. Alternative RNA splicing may also contribute to expansion of the immune repertoire.

Original languageEnglish (US)
Pages (from-to)159-165
Number of pages7
JournalScience
Volume298
Issue number5591
DOIs
StatePublished - Oct 4 2002
Externally publishedYes

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Anopheles gambiae
Immunity
Genes
Alternative Splicing
Drosophila melanogaster
Innate Immunity
Insects
Life Style
Signal Transduction
Pressure

ASJC Scopus subject areas

  • General

Cite this

Christophides, G. K., Zdobnov, E., Barillas-Mury, C., Birney, E., Blandin, S., Blass, C., ... Kafatos, F. C. (2002). Immunity-related genes and gene families in Anopheles gambiae. Science, 298(5591), 159-165. https://doi.org/10.1126/science.1077136

Immunity-related genes and gene families in Anopheles gambiae. / Christophides, George K.; Zdobnov, Evgeny; Barillas-Mury, Carolina; Birney, Ewan; Blandin, Stephanie; Blass, Claudia; Brey, Paul T.; Collins, Frank H.; Danielli, Alberto; Dimopoulos, George; Hetru, Charles; Hoa, Ngo T.; Hoffmann, Jules A.; Kanzok, Stefan M.; Letunic, Ivica; Levashina, Elena A.; Loukeris, Thanasis G.; Lycett, Gareth; Meister, Stephan; Michel, Kristin; Moita, Luis F.; Müller, Hans Michael; Osta, Mike A.; Paskewitz, Susan M.; Reichhart, Jean Marc; Rzhetsky, Andrey; Troxler, Laurent; Vernick, Kenneth D.; Vlachou, Dina; Volz, Jennifer; Von Mering, Christian; Xu, Jiannong; Zheng, Liangbiao; Bork, Peer; Kafatos, Fotis C.

In: Science, Vol. 298, No. 5591, 04.10.2002, p. 159-165.

Research output: Contribution to journalArticle

Christophides, GK, Zdobnov, E, Barillas-Mury, C, Birney, E, Blandin, S, Blass, C, Brey, PT, Collins, FH, Danielli, A, Dimopoulos, G, Hetru, C, Hoa, NT, Hoffmann, JA, Kanzok, SM, Letunic, I, Levashina, EA, Loukeris, TG, Lycett, G, Meister, S, Michel, K, Moita, LF, Müller, HM, Osta, MA, Paskewitz, SM, Reichhart, JM, Rzhetsky, A, Troxler, L, Vernick, KD, Vlachou, D, Volz, J, Von Mering, C, Xu, J, Zheng, L, Bork, P & Kafatos, FC 2002, 'Immunity-related genes and gene families in Anopheles gambiae', Science, vol. 298, no. 5591, pp. 159-165. https://doi.org/10.1126/science.1077136
Christophides GK, Zdobnov E, Barillas-Mury C, Birney E, Blandin S, Blass C et al. Immunity-related genes and gene families in Anopheles gambiae. Science. 2002 Oct 4;298(5591):159-165. https://doi.org/10.1126/science.1077136
Christophides, George K. ; Zdobnov, Evgeny ; Barillas-Mury, Carolina ; Birney, Ewan ; Blandin, Stephanie ; Blass, Claudia ; Brey, Paul T. ; Collins, Frank H. ; Danielli, Alberto ; Dimopoulos, George ; Hetru, Charles ; Hoa, Ngo T. ; Hoffmann, Jules A. ; Kanzok, Stefan M. ; Letunic, Ivica ; Levashina, Elena A. ; Loukeris, Thanasis G. ; Lycett, Gareth ; Meister, Stephan ; Michel, Kristin ; Moita, Luis F. ; Müller, Hans Michael ; Osta, Mike A. ; Paskewitz, Susan M. ; Reichhart, Jean Marc ; Rzhetsky, Andrey ; Troxler, Laurent ; Vernick, Kenneth D. ; Vlachou, Dina ; Volz, Jennifer ; Von Mering, Christian ; Xu, Jiannong ; Zheng, Liangbiao ; Bork, Peer ; Kafatos, Fotis C. / Immunity-related genes and gene families in Anopheles gambiae. In: Science. 2002 ; Vol. 298, No. 5591. pp. 159-165.
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AU - Zdobnov, Evgeny

AU - Barillas-Mury, Carolina

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AU - Blandin, Stephanie

AU - Blass, Claudia

AU - Brey, Paul T.

AU - Collins, Frank H.

AU - Danielli, Alberto

AU - Dimopoulos, George

AU - Hetru, Charles

AU - Hoa, Ngo T.

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AU - Levashina, Elena A.

AU - Loukeris, Thanasis G.

AU - Lycett, Gareth

AU - Meister, Stephan

AU - Michel, Kristin

AU - Moita, Luis F.

AU - Müller, Hans Michael

AU - Osta, Mike A.

AU - Paskewitz, Susan M.

AU - Reichhart, Jean Marc

AU - Rzhetsky, Andrey

AU - Troxler, Laurent

AU - Vernick, Kenneth D.

AU - Vlachou, Dina

AU - Volz, Jennifer

AU - Von Mering, Christian

AU - Xu, Jiannong

AU - Zheng, Liangbiao

AU - Bork, Peer

AU - Kafatos, Fotis C.

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