Immunity of cholera in man: Relative role of antibacterial versus antitoxic immunity

Myron M. Levine, David R. Nalin, John P. Craig, David Hoover, Eric J. Bergquist, Daniel Waterman, H. Preston Holley, Richard B. Hornick, Nathaniel P. Pierce, Joseph P. Libonati

Research output: Contribution to journalArticlepeer-review

Abstract

Purified cholera toxoid is antigenic when given enterally and orally. Purified toxoid fails to provide protection against experimental challenge. Clinical cholera confers formidable protection against homologous or heterologous rechallenge. Failure to culture vibrios from intestinal fluid or stool of re-challenge volunteers suggests that the predominant immune mechanism is antibacterial rather than antitoxic.

Original languageEnglish (US)
Pages (from-to)3-9
Number of pages7
JournalTransactions of the Royal Society of Tropical Medicine and Hygiene
Volume73
Issue number1
DOIs
StatePublished - 1979

ASJC Scopus subject areas

  • Parasitology
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Immunity of cholera in man: Relative role of antibacterial versus antitoxic immunity'. Together they form a unique fingerprint.

Cite this