Immunity and hepatitis C: A review

Research output: Contribution to journalArticle

Abstract

Hepatitis C virus (HCV) is a major cause of chronic hepatitis and hepatocellular carcinoma worldwide. Due to shared transmission routes, the prevalence of HCV is especially high among individuals infected with HIV. HIV uninfected individuals spontaneously clear HCV approximately 30 % of the time, while the rate of control in HIV infected individuals who subsequently acquire HCV is substantially lower. In addition, complications of HCV are more frequent in those with HIV infection, making liver disease the leading cause of non-AIDS-related death in HIV infected individuals. This review summarizes recent advances in understanding the role of the innate and adaptive immune responses to HCV in those with and without HIV. Further defining the interaction between hepatitis C and the host immune system will potentially reveal insights into HCV pathogenesis and the host's ability to prevent persistent infection, as well as direct the development of vaccines.

Original languageEnglish (US)
Pages (from-to)51-58
Number of pages8
JournalCurrent HIV/AIDS reports
Volume10
Issue number1
DOIs
StatePublished - Mar 1 2013

Keywords

  • Acute infection
  • Adaptive immune response
  • B cell response
  • Cellular immunity
  • Chronic infection
  • Coinfection
  • HCV
  • HIV
  • HIV-HCV coinfection
  • Hepatitis
  • Hepatitis C
  • IFN
  • Immunity
  • Innate immune response
  • Interferons
  • Interleukin 18
  • Interleukin 28B
  • Liver disease
  • Neutralizing antibodies
  • SVR
  • Spontaneous clearance
  • T cell response
  • Treatment response
  • Vaccination
  • Viral hepatitis
  • Virus

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

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