Immunity against Staphylococcus aureus cutaneous infections

Lloyd S. Miller; John S. Cho

doi:10.1038/nri3010

Immunity against Staphylococcus aureus cutaneous infections

Lloyd S. Miller, John S. Cho

Research output: Contribution to journal › Review article › peer-review

238 Scopus citations

Abstract

Complications arising from cutaneous and soft tissue infections with Staphylococcus aureus are a major clinical problem owing to the high incidence of these infections and the widespread emergence of antibiotic-resistant bacterial strains. If prophylactic vaccines or immunotherapy for certain patient populations are to be developed as an alternative to antibiotics, it will be essential to better understand the immune mechanisms that provide protection against S. aureus skin infections. Recent discoveries have identified a key role for interleukin-1 (IL-1)-and IL-17-mediated immune responses in promoting neutrophil recruitment to the site of infection in the skin, a process that is required for host defence and bacterial clearance. This Review describes these new insights and discusses their potential impact on immune-based therapies and vaccination strategies.

Original language	English (US)
Pages (from-to)	505-518
Number of pages	14
Journal	Nature Reviews Immunology
Volume	11
Issue number	8
DOIs	https://doi.org/10.1038/nri3010
State	Published - Aug 2011
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1038/nri3010

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abstract = "Complications arising from cutaneous and soft tissue infections with Staphylococcus aureus are a major clinical problem owing to the high incidence of these infections and the widespread emergence of antibiotic-resistant bacterial strains. If prophylactic vaccines or immunotherapy for certain patient populations are to be developed as an alternative to antibiotics, it will be essential to better understand the immune mechanisms that provide protection against S. aureus skin infections. Recent discoveries have identified a key role for interleukin-1 (IL-1)-and IL-17-mediated immune responses in promoting neutrophil recruitment to the site of infection in the skin, a process that is required for host defence and bacterial clearance. This Review describes these new insights and discusses their potential impact on immune-based therapies and vaccination strategies.",

author = "Miller, {Lloyd S.} and Cho, {John S.}",

note = "Funding Information: L.S.M. is supported by grants from the US National Institutes of Health (R01 AI078910 and R03 AR054534). J.S.C. is supported by the Dermatology Scientist Training Program at UCLA from the US National Institutes of Health (T32 AR058921).",

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AB - Complications arising from cutaneous and soft tissue infections with Staphylococcus aureus are a major clinical problem owing to the high incidence of these infections and the widespread emergence of antibiotic-resistant bacterial strains. If prophylactic vaccines or immunotherapy for certain patient populations are to be developed as an alternative to antibiotics, it will be essential to better understand the immune mechanisms that provide protection against S. aureus skin infections. Recent discoveries have identified a key role for interleukin-1 (IL-1)-and IL-17-mediated immune responses in promoting neutrophil recruitment to the site of infection in the skin, a process that is required for host defence and bacterial clearance. This Review describes these new insights and discusses their potential impact on immune-based therapies and vaccination strategies.

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Immunity against Staphylococcus aureus cutaneous infections

Abstract

ASJC Scopus subject areas

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