Immune therapy in GI malignancies: A review

Judy Wang, Kim A. Reiss, Rina Khatri, Elizabeth Jaffee, Dan Laheru

Research output: Contribution to journalReview articlepeer-review

Abstract

The balance between tumor-promoting and tumor-suppressing immune responses and the difference between them ultimately determine whether a cancer escapes immune recognition mechanisms. Defining the complex relationships between the tumor itself, the tumor environment, and the immune system has been critical in facilitating the development of successful immunotherapies. This review explores the role of oncogenes in inducing cancer-associated inflammation, the local and systemic factors that lead to immune suppression, and immunotherapy approaches to overcome immune privilege.

Original languageEnglish (US)
Pages (from-to)1745-1753
Number of pages9
JournalJournal of Clinical Oncology
Volume33
Issue number16
DOIs
StatePublished - Jun 1 2015

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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