Immune responses to RNA-virus infections of the CNS

Research output: Contribution to journalReview articlepeer-review

Abstract

A successful outcome for the host of virus infection of the central nervous system (CNS) requires the elimination of the virus without damage to essential non-renewable cells, such as neurons. As a result, inflammatory responses must be tightly controlled, and many unique mechanisms seem to contribute to this control. In addition to being important causes of human disease, RNA viruses that infect the CNS provide useful models in which to study immune responses in the CNS. Recent work has shown the importance of innate immune responses in the CNS in controlling virus infection. And advances have been made in assessing the relative roles of cytotoxic T cells, antibodies and cytokines in the clearance of viruses from neurons, glial cells and meningeal cells.

Original languageEnglish (US)
Pages (from-to)493-502
Number of pages10
JournalNature Reviews Immunology
Volume3
Issue number6
DOIs
StatePublished - Jun 2003

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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