Immune responses to oral poliovirus vaccine in HIV-exposed uninfected Zimbabwean infants

James A. Church, Sandra Rukobo, Margaret Govha, Marya P. Carmolli, Sean A. Diehl, Bernard Chasekwa, Robert Ntozini, Kuda Mutasa, Jean H. Humphrey, Beth D. Kirkpatrick, Andrew J. Prendergast

Research output: Contribution to journalArticlepeer-review

Abstract

It remains uncertain whether HIV-exposed uninfected (HEU) infants have impaired responses to oral vaccines. We performed a cross-sectional study of 6-month-old infants recruited at birth to the ZVITAMBO trial in Zimbabwe between 1997–2001, before introduction of prevention of mother-to-child transmission interventions. We measured poliovirus-specific IgA to type 1–3 polio strains by semi-quantitative capture ELISA in cryopreserved serum samples collected from 85 HEU and 101 HIV-unexposed infants at 6 months of age, one month after their last immunisation with trivalent OPV. Almost all infants were breastfed, with the majority in both groups mixed breastfed (70.6% HEU versus 71.3% HIV-unexposed). Median (IQR) vaccine titers for HEU and HIV-unexposed infants were 1592 (618–4896) vs. 1774 (711–5431) for Sabin 1 (P = 0.46); 1895 (810–4398) vs. 2308 (1081–4283) for Sabin 2 (P = 0.52); and 1798 (774–4192) vs. 2260 (996–5723) for Sabin 3 (P = 0.18). There were no significant differences in vaccine titers between HEU and HIV-unexposed infants, suggesting that vertical HIV exposure does not impact oral poliovirus vaccine immunogenicity.

Original languageEnglish (US)
Pages (from-to)2543-2547
Number of pages5
JournalHuman Vaccines and Immunotherapeutics
Volume13
Issue number11
DOIs
StatePublished - Nov 2 2017

Keywords

  • Africa
  • HIV
  • OPV
  • infants
  • oral vaccine
  • poliovirus

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology

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