TY - JOUR
T1 - Immune Responses to Acute Alphavirus Infection of the Central Nervous System
T2 - Sindbis Virus Encephalitis in Mice
AU - Griffin, Diane E.
AU - Mokhtarian, Foroozan
AU - Park, Mahin M.
AU - Hirsch, Robert L.
N1 - Funding Information:
This work was supported in part by a grant from the National Multiple Sclerosis Society and Research Grants NS-15721 and NS-07000 from the National Institutes of Health.
PY - 1983/1/1
Y1 - 1983/1/1
N2 - Sindbis virus is an alphavirus that produces an acute nonfatal encephalitis in mice. The local immune responses to this virus are both cellular and humoral. The cellular response is characterized by an infiltration of mononuclear cells into the cerebrospinal fluid (CSF), the meninges, and the brain parenchyma. This inflammatory response is initiated by sensitized T-lymphocytes that are stimulated by exposure to viral antigen to produce a lymphokine, which is chemotactic for mononuclear cells. These T-cells may also produce a lymphokine that stimulates mast cells to release vasoactive amines, which facilitate monocyte entry from the blood. Inflammation is not necessary for clearance of virus from the brain. Humoral immune responses are initially systemic and, in the central nervous system (CNS), reflect transudation of serum antibody. During recovery, there is local production of antiviral IgA as well as IgG.
AB - Sindbis virus is an alphavirus that produces an acute nonfatal encephalitis in mice. The local immune responses to this virus are both cellular and humoral. The cellular response is characterized by an infiltration of mononuclear cells into the cerebrospinal fluid (CSF), the meninges, and the brain parenchyma. This inflammatory response is initiated by sensitized T-lymphocytes that are stimulated by exposure to viral antigen to produce a lymphokine, which is chemotactic for mononuclear cells. These T-cells may also produce a lymphokine that stimulates mast cells to release vasoactive amines, which facilitate monocyte entry from the blood. Inflammation is not necessary for clearance of virus from the brain. Humoral immune responses are initially systemic and, in the central nervous system (CNS), reflect transudation of serum antibody. During recovery, there is local production of antiviral IgA as well as IgG.
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U2 - 10.1016/S0079-6123(08)63847-9
DO - 10.1016/S0079-6123(08)63847-9
M3 - Article
C2 - 6320262
AN - SCOPUS:0021012179
SN - 0079-6123
VL - 59
SP - 11
EP - 21
JO - Progress in brain research
JF - Progress in brain research
IS - C
ER -