Immune response to intradermally injected inactivated poliovirus vaccine

B. U. Samuel, Thomas Cherian, G. Sridharan, P. Mukundan, T. J. John

Research output: Contribution to journalArticle

Abstract

Immune response to intradermal inoculation of a fractional dose of inactivated poliovirus vaccine (IPV) was measured in 8 adults and 10 children who were previously immune. A striking 4-fold to 1024-fold antibody booster response to all 3 poliovirus serotypes was found in 15 subjects and a similar response to 2 poliovirus serotypes occurred in the other 3 children. Induration and erythema of 3 mm diameter or above, indicative of a cell-mediated immune response, was seen in 12 subjects. Intradermal inoculation of IPV may be a useful technique for secondary immunisation programmes against polio and its use for primary immunisation merits investigation.

Original languageEnglish (US)
Pages (from-to)343-344
Number of pages2
JournalThe Lancet
Volume338
Issue number8763
DOIs
StatePublished - Aug 10 1991
Externally publishedYes

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Inactivated Poliovirus Vaccine
Poliovirus
Secondary Immunization
Immunization Programs
Poliomyelitis
Erythema
Antibody Formation
Immunization
Serogroup

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Immune response to intradermally injected inactivated poliovirus vaccine. / Samuel, B. U.; Cherian, Thomas; Sridharan, G.; Mukundan, P.; John, T. J.

In: The Lancet, Vol. 338, No. 8763, 10.08.1991, p. 343-344.

Research output: Contribution to journalArticle

Samuel, BU, Cherian, T, Sridharan, G, Mukundan, P & John, TJ 1991, 'Immune response to intradermally injected inactivated poliovirus vaccine', The Lancet, vol. 338, no. 8763, pp. 343-344. https://doi.org/10.1016/0140-6736(91)90480-D
Samuel, B. U. ; Cherian, Thomas ; Sridharan, G. ; Mukundan, P. ; John, T. J. / Immune response to intradermally injected inactivated poliovirus vaccine. In: The Lancet. 1991 ; Vol. 338, No. 8763. pp. 343-344.
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