Immune response to intradermally injected inactivated poliovirus vaccine

B. U. Samuel; T. Cherian; G. Sridharan; P. Mukundan; T. J. John

doi:10.1016/0140-6736(91)90480-D

Immune response to intradermally injected inactivated poliovirus vaccine

B. U. Samuel, T. Cherian, G. Sridharan, P. Mukundan, T. J. John

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Abstract

Immune response to intradermal inoculation of a fractional dose of inactivated poliovirus vaccine (IPV) was measured in 8 adults and 10 children who were previously immune. A striking 4-fold to 1024-fold antibody booster response to all 3 poliovirus serotypes was found in 15 subjects and a similar response to 2 poliovirus serotypes occurred in the other 3 children. Induration and erythema of 3 mm diameter or above, indicative of a cell-mediated immune response, was seen in 12 subjects. Intradermal inoculation of IPV may be a useful technique for secondary immunisation programmes against polio and its use for primary immunisation merits investigation.

Original language	English (US)
Pages (from-to)	343-344
Number of pages	2
Journal	The Lancet
Volume	338
Issue number	8763
DOIs	https://doi.org/10.1016/0140-6736(91)90480-D
State	Published - Aug 10 1991
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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abstract = "Immune response to intradermal inoculation of a fractional dose of inactivated poliovirus vaccine (IPV) was measured in 8 adults and 10 children who were previously immune. A striking 4-fold to 1024-fold antibody booster response to all 3 poliovirus serotypes was found in 15 subjects and a similar response to 2 poliovirus serotypes occurred in the other 3 children. Induration and erythema of 3 mm diameter or above, indicative of a cell-mediated immune response, was seen in 12 subjects. Intradermal inoculation of IPV may be a useful technique for secondary immunisation programmes against polio and its use for primary immunisation merits investigation.",

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AU - Samuel, B. U.

AU - Cherian, T.

AU - Sridharan, G.

AU - Mukundan, P.

AU - John, T. J.

PY - 1991/8/10

Y1 - 1991/8/10

N2 - Immune response to intradermal inoculation of a fractional dose of inactivated poliovirus vaccine (IPV) was measured in 8 adults and 10 children who were previously immune. A striking 4-fold to 1024-fold antibody booster response to all 3 poliovirus serotypes was found in 15 subjects and a similar response to 2 poliovirus serotypes occurred in the other 3 children. Induration and erythema of 3 mm diameter or above, indicative of a cell-mediated immune response, was seen in 12 subjects. Intradermal inoculation of IPV may be a useful technique for secondary immunisation programmes against polio and its use for primary immunisation merits investigation.

AB - Immune response to intradermal inoculation of a fractional dose of inactivated poliovirus vaccine (IPV) was measured in 8 adults and 10 children who were previously immune. A striking 4-fold to 1024-fold antibody booster response to all 3 poliovirus serotypes was found in 15 subjects and a similar response to 2 poliovirus serotypes occurred in the other 3 children. Induration and erythema of 3 mm diameter or above, indicative of a cell-mediated immune response, was seen in 12 subjects. Intradermal inoculation of IPV may be a useful technique for secondary immunisation programmes against polio and its use for primary immunisation merits investigation.

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Immune response to intradermally injected inactivated poliovirus vaccine

Abstract

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