Immune response to Campylobacter jejuni in a rural community in Thailand

M. J. Blaser, D. N. Taylor, P. Echeverria

Research output: Contribution to journalArticle

Abstract

We studied the prevalence of antibodies to Campylobacter jejuni in serum from healthy Thai villagers by using enzyme-linked immunosorbent assays with C. jejuni surface proteins as antigens. Levels of C. jejuni-specific IgA rose progressively through life, IgG peaked in the second year of life and then fell, and IgM peaked during late childhood and the teenage years. These findings confirm results observed in Bangladeshi children, and they suggest there is intense early exposure and continued exposure through life. The ratio of C. jejuni-specific IgA to total IgA was constant in all age groups while the ratio of specific IgG and IgM followed the same age-related pattern as the levels of antibody to C. jejuni. The age-related discordance between the C. jejuni-specific IgA and IgG levels observed in this and the previous study are at present unexplained.

Original languageEnglish (US)
Pages (from-to)249-254
Number of pages6
JournalJournal of Infectious Diseases
Volume153
Issue number2
StatePublished - 1986
Externally publishedYes

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Campylobacter jejuni
Rural Population
Thailand
Immunoglobulin A
Immunoglobulin G
Immunoglobulin M
Antibodies
Membrane Proteins
Age Groups
Enzyme-Linked Immunosorbent Assay
Antigens
Serum

ASJC Scopus subject areas

  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Blaser, M. J., Taylor, D. N., & Echeverria, P. (1986). Immune response to Campylobacter jejuni in a rural community in Thailand. Journal of Infectious Diseases, 153(2), 249-254.

Immune response to Campylobacter jejuni in a rural community in Thailand. / Blaser, M. J.; Taylor, D. N.; Echeverria, P.

In: Journal of Infectious Diseases, Vol. 153, No. 2, 1986, p. 249-254.

Research output: Contribution to journalArticle

Blaser, MJ, Taylor, DN & Echeverria, P 1986, 'Immune response to Campylobacter jejuni in a rural community in Thailand', Journal of Infectious Diseases, vol. 153, no. 2, pp. 249-254.
Blaser, M. J. ; Taylor, D. N. ; Echeverria, P. / Immune response to Campylobacter jejuni in a rural community in Thailand. In: Journal of Infectious Diseases. 1986 ; Vol. 153, No. 2. pp. 249-254.
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