Immune response against vaccinia virus in rhesus monkeys: No evidence for primary MHC-restricted cytolytic T cells

Lothar Stitz, Rolf Zinkernagel, Charles M. Balch, Reinier L.H. Bolhuis, Hans Balnera

Research output: Contribution to journalArticlepeer-review

Abstract

Rhesus monkeys were tested in vitro for their cellular immune response after infection with vaccinia virus, employing lymphocyte preparations from various lymphoid tissues. Although virus-infected target cells were lysed by lymphoid cells from immunized, but not from uninfected, rhesus monkeys, we could neither find evidence for MHC-restricted T cells nor for antibody-dependent cellular cytotoxicity. Kinetics of target cell lysis, the killing patterns of immune lymphocytes measured on syngeneic, allogeneic, and xenogeneic target cells, and the influence of protein A on cytotoxic activity in vitro suggest induction predominantly of natural killer cells in vivo which exhibit lytic activity on virus-infected target cells in vitro.

Original languageEnglish (US)
Pages (from-to)237-250
Number of pages14
JournalPathobiology
Volume52
Issue number4
DOIs
StatePublished - 1984
Externally publishedYes

Keywords

  • Cellular immune response
  • Rhesus monkey
  • Vaccinia virus

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Cell Biology

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