Immune recovery after starting ART in HIV-infected patients presenting and not presenting with tuberculosis in South Africa

Michael Schomaker; Matthias Egger; Mhairi Maskew; Daniela Garone; Hans Prozesky; Christopher J. Hoffmann; Andrew Boulle; Lukas Fenner

doi:10.1097/QAI.0b013e318288b39d

Immune recovery after starting ART in HIV-infected patients presenting and not presenting with tuberculosis in South Africa

Michael Schomaker, Matthias Egger, Mhairi Maskew, Daniela Garone, Hans Prozesky, Christopher J. Hoffmann, Andrew Boulle, Lukas Fenner

School of Medicine

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

We studied the immune response after starting antiretroviral treatment (ART) in 15,646 HIV-infected patients with or without tuberculosis (TB) at presentation in 3 ART programs in South Africa between 2003 and 2010. Patients presenting with TB had similar increases in CD4 cells compared with all other patients (adjusted difference 4.9 cells/μL per 6 months, 95% confidence interval: 0.2 to 9.7). Younger age, advanced clinical stage, female sex, and lower CD4 cell count at ART start were all associated with steeper CD4 slopes. In South Africa, HIV-infected patients presenting with TB experience immune recovery after starting ART that is no worse than in other patients.

Original language	English (US)
Pages (from-to)	142-145
Number of pages	4
Journal	Journal of Acquired Immune Deficiency Syndromes
Volume	63
Issue number	1
DOIs	https://doi.org/10.1097/QAI.0b013e318288b39d
State	Published - May 1 2013

Keywords

CD4 cell count
HIV
antiretroviral treatment
immune response
linear mixed model
tuberculosis

ASJC Scopus subject areas

Infectious Diseases
Pharmacology (medical)

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10.1097/QAI.0b013e318288b39d

Cite this

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abstract = "We studied the immune response after starting antiretroviral treatment (ART) in 15,646 HIV-infected patients with or without tuberculosis (TB) at presentation in 3 ART programs in South Africa between 2003 and 2010. Patients presenting with TB had similar increases in CD4 cells compared with all other patients (adjusted difference 4.9 cells/μL per 6 months, 95% confidence interval: 0.2 to 9.7). Younger age, advanced clinical stage, female sex, and lower CD4 cell count at ART start were all associated with steeper CD4 slopes. In South Africa, HIV-infected patients presenting with TB experience immune recovery after starting ART that is no worse than in other patients.",

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AU - Prozesky, Hans

AU - Hoffmann, Christopher J.

AU - Boulle, Andrew

AU - Fenner, Lukas

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Immune recovery after starting ART in HIV-infected patients presenting and not presenting with tuberculosis in South Africa

Abstract

Keywords

ASJC Scopus subject areas

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