Immune recovery after starting ART in HIV-infected patients presenting and not presenting with tuberculosis in South Africa

Michael Schomaker, Matthias Egger, Mhairi Maskew, Daniela Garone, Hans Prozesky, Christopher J. Hoffmann, Andrew Boulle, Lukas Fenner

Research output: Contribution to journalArticle

Abstract

We studied the immune response after starting antiretroviral treatment (ART) in 15,646 HIV-infected patients with or without tuberculosis (TB) at presentation in 3 ART programs in South Africa between 2003 and 2010. Patients presenting with TB had similar increases in CD4 cells compared with all other patients (adjusted difference 4.9 cells/μL per 6 months, 95% confidence interval: 0.2 to 9.7). Younger age, advanced clinical stage, female sex, and lower CD4 cell count at ART start were all associated with steeper CD4 slopes. In South Africa, HIV-infected patients presenting with TB experience immune recovery after starting ART that is no worse than in other patients.

Original languageEnglish (US)
Pages (from-to)142-145
Number of pages4
JournalJournal of acquired immune deficiency syndromes
Volume63
Issue number1
DOIs
StatePublished - May 1 2013

Keywords

  • CD4 cell count
  • HIV
  • antiretroviral treatment
  • immune response
  • linear mixed model
  • tuberculosis

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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