Cardiac myosin-induced murine myocarditis provides a useful model for assessing the role of immune mediators in the development of inflammatory heart disease. Myocarditis is characterized by leucocyte infiltration, fibrosis, and cardiomyocyte death, which collectively lead to deterioration of both systolic and diastolic function as assessed by pressure-volume relations. In severe cases, disease progresses to dilated cardiomyopathy and heart failure. Key factors that promote disease include complement, tumour necrosis factor-alpha, interleukin-4, and interleukin-12. Factors found to suppress myocarditis include interferon-gamma, interleukin-10, and cyotoxic T lymphocyte antigen-4. Final disease outcome is determined by the interplay of these immune mediators.
- Knockout mice
- Pressure-volume relations
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine