Immune-mediated tumor evolution: Nanog links the emergence of a stem like cancer cell state and immune evasion

Chih Ping Mao; T. C. Wu; Kwon Ho Song; Tae Woo Kim

doi:10.4161/21624011.2014.947871

Immune-mediated tumor evolution: Nanog links the emergence of a stem like cancer cell state and immune evasion

Chih Ping Mao, T. C. Wu, Kwon Ho Song, Tae Woo Kim

School of Medicine

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

Tumor cells undergo molecular evolution under immune pressure. Using a murine metastatic lung cancer model, we recently reported that evolutionary pressure enforced through vaccination incites gain of Nanog, a master transcription factor that mediates both emergence of a stem-like cancer cell state and immune evasion. Thus, therapeutic strategies aiming to blunt NANOG's expression in patient tumors may improve the clinical management of cancer.

Original language	English (US)
Article number	e947871
Journal	OncoImmunology
Volume	3
Issue number	7
DOIs	https://doi.org/10.4161/21624011.2014.947871
State	Published - 2014

Keywords

Cytotoxic T lymphocytes
Immune surveillance
Immune-resistant
Nanog
Stem-like phenotype

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

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10.4161/21624011.2014.947871

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abstract = "Tumor cells undergo molecular evolution under immune pressure. Using a murine metastatic lung cancer model, we recently reported that evolutionary pressure enforced through vaccination incites gain of Nanog, a master transcription factor that mediates both emergence of a stem-like cancer cell state and immune evasion. Thus, therapeutic strategies aiming to blunt NANOG's expression in patient tumors may improve the clinical management of cancer.",

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AU - Kim, Tae Woo

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AB - Tumor cells undergo molecular evolution under immune pressure. Using a murine metastatic lung cancer model, we recently reported that evolutionary pressure enforced through vaccination incites gain of Nanog, a master transcription factor that mediates both emergence of a stem-like cancer cell state and immune evasion. Thus, therapeutic strategies aiming to blunt NANOG's expression in patient tumors may improve the clinical management of cancer.

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Immune-mediated tumor evolution: Nanog links the emergence of a stem like cancer cell state and immune evasion

Abstract

Keywords

ASJC Scopus subject areas

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