Immune-mediated clearance of virus from the central nervous system

Gwendolyn K. Binder; Diane E. Griffin

doi:10.1016/S1286-4579(03)00047-9

Immune-mediated clearance of virus from the central nervous system

Gwendolyn K. Binder, Diane E. Griffin

Bloomberg School of Public Health

Research output: Contribution to journal › Review article › peer-review

30 Scopus citations

Abstract

Immune-mediated clearance of virus from the central nervous system (CNS) differs from that of the other organs. Mechanisms of virus control are largely dependent upon the target cell type. Although cytolytic T lymphocytes may mediate clearance of virus from glial cells, non-cytolytic mechanisms mediated by antibody and cytokines dominate clearance from neurons.

Original language	English (US)
Pages (from-to)	439-448
Number of pages	10
Journal	Microbes and Infection
Volume	5
Issue number	5
DOIs	https://doi.org/10.1016/S1286-4579(03)00047-9
State	Published - Apr 2003

Keywords

Central nervous system
Immune system
Virus replication

ASJC Scopus subject areas

Microbiology
Immunology
Infectious Diseases

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10.1016/S1286-4579(03)00047-9

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title = "Immune-mediated clearance of virus from the central nervous system",

abstract = "Immune-mediated clearance of virus from the central nervous system (CNS) differs from that of the other organs. Mechanisms of virus control are largely dependent upon the target cell type. Although cytolytic T lymphocytes may mediate clearance of virus from glial cells, non-cytolytic mechanisms mediated by antibody and cytokines dominate clearance from neurons.",

keywords = "Central nervous system, Immune system, Virus replication",

author = "Binder, {Gwendolyn K.} and Griffin, {Diane E.}",

note = "Funding Information: We would like to thank Elizabeth Slaterbeck of the Department of Pathology for her technical assistance in digital imaging. Research from the authors{\textquoteright} laboratory was supported by a research grant from the National Institutes of Health (NS38932).",

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AU - Griffin, Diane E.

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AB - Immune-mediated clearance of virus from the central nervous system (CNS) differs from that of the other organs. Mechanisms of virus control are largely dependent upon the target cell type. Although cytolytic T lymphocytes may mediate clearance of virus from glial cells, non-cytolytic mechanisms mediated by antibody and cytokines dominate clearance from neurons.

KW - Central nervous system

KW - Immune system

KW - Virus replication

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Immune-mediated clearance of virus from the central nervous system

Abstract

Keywords

ASJC Scopus subject areas

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