Immune Mechanisms in the Pathogenesis of Pulmonary Tuberculosis

Arthur M. Dannenberg

Research output: Contribution to journalArticle

Abstract

The pathogenesis of pulmonary tuberculosis and the beneficial and detrimental effects of the host's cell-mediated immune response in this disease are reviewed. Thbercle bacilli are hardy facultative intracellular pathogens that live and multiply in nonactivated macrophages. Before tubercle bacilli can be destroyed by macrophages, these cells must be activated by T lymphocytes and their lymphokines. Such activation is the essence of cell-mediated immunity. Cell-mediated immunity also has a detrimental component, called delayed-type hypersensitivity. This component causes caseous necrosis of host tissues whenever the bacillary antigens reach high levels. Such levels occur intracellularly in macrophages of highly susceptible hosts and extracellularly in liquefied caseous foci of resistant hosts. Vaccines containing antigens that create more cell-mediated immunity and less delayed-type hypersensitivity are greatly needed.

Original languageEnglish (US)
Pages (from-to)S369-S378
JournalReviews of Infectious Diseases
Volume11
DOIs
StatePublished - 1989

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Pulmonary Tuberculosis
Cellular Immunity
Macrophages
Delayed Hypersensitivity
Bacillus
Antigens
Lymphokines
Necrosis
Vaccines
T-Lymphocytes

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Immune Mechanisms in the Pathogenesis of Pulmonary Tuberculosis. / Dannenberg, Arthur M.

In: Reviews of Infectious Diseases, Vol. 11, 1989, p. S369-S378.

Research output: Contribution to journalArticle

Dannenberg, Arthur M. / Immune Mechanisms in the Pathogenesis of Pulmonary Tuberculosis. In: Reviews of Infectious Diseases. 1989 ; Vol. 11. pp. S369-S378.
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