@article{846e834e45d64cef9b45e314ac2b3563,
title = "Immune-globulin prophylaxis of respiratory syncytial virus infection in patients undergoing stem-cell transplantation",
abstract = "Thirty-two patients undergoing allogeneic hematopoietic stem-cell transplantation were given respiratory syncytial virus (RSV) immune globulin (RSVIG) at the time of transplantation and again 3 weeks later. Antibody titers to RSV, human parainfluenza virus 3, measles, and influenza H1N1, H3N2, and B were measured prior to administration of RSVIG and 6 more times over the course of the subsequent 6 weeks. Baseline antiviral titers and increases in antibody after administration of RSVIG were extremely variable for all the viruses. In 18 patients in whom the baseline titers of antibody titers to RSV-F protein were 1:640-1:2048, there was a 7.7-fold initial increase in these titers after the first dose of RSVIG, compared with a 2.1-fold increase in 14 patients with baseline titers of 1:4096-1:20,840; increases in titers of antibody against the other viruses after the first dose of RSVIG reflected similar variability. The subset of patients with the lowest titers appear to receive the greatest benefit from administration of RSVIG.",
author = "Karoll Cortez and Murphy, {B. R.} and Almeida, {K. N.} and J. Beeler and Levandowski, {R. A.} and Gill, {V. J.} and Childs, {R. W.} and Barrett, {A. J.} and M. Smolskis and Bennett, {J. E.}",
note = "Funding Information: 1Clinical Mycology Section, Laboratory of Clinical Investigation, and 2Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, 3Microbiology Service, Department of Laboratory Medicine, Warren Grant Magnuson Clinical Center, and 4Stem Cell Allotransplant Unit, Hematology Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, and 5Laboratory of Pediatric and Respiratory Virus Diseases, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland Funding Information: We thank Jeanne Preuss (Division of Virology, Department of Laboratory Medicine, Clinical Center, National Institutes of Health [NIH]) for her skillful work and sample management during the trial, Steve Whitehead (Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, NIH) for his help with measurement of titers for respiratory syncytial virus-F protein and for neutralizing antibody, and Susette Audet (Laboratory of Pediatric and Respiratory Virus Diseases, Division of Viral Products, Center for Biologics Evaluation and Research, Food and Drug Administration) for her expert technical assistance in the measurement of measles neutralizing antibody titers.",
year = "2002",
month = sep,
day = "15",
doi = "10.1086/342412",
language = "English (US)",
volume = "186",
pages = "834--838",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "6",
}