Abstract
Hyporesponsiveness to mycobacterial antigens occurs in some patients with tuberculosis. Active immunosuppression by monocytes, T-lymphocytes, and serum is evident and may be a critical factor in anergy. The molecular basis for depressed responsiveness to tuberculin antigens is uncertain, but may involve aberrant surface expression of the HLA-DR gene product on adherent mono-nuclear cells and abnormalities in immune induction and the cytokine cascade.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 138-141 |
| Number of pages | 4 |
| Journal | The Journal of Laboratory and Clinical Medicine |
| Volume | 108 |
| Issue number | 2 |
| State | Published - 1986 |
| Externally published | Yes |
ASJC Scopus subject areas
- General Medicine
- Pathology and Forensic Medicine