Immune dysregulation in human tuberculosis

Jerrold J. Ellner

Research output: Contribution to journalArticlepeer-review

Abstract

Hyporesponsiveness to mycobacterial antigens occurs in some patients with tuberculosis. Active immunosuppression by monocytes, T-lymphocytes, and serum is evident and may be a critical factor in anergy. The molecular basis for depressed responsiveness to tuberculin antigens is uncertain, but may involve aberrant surface expression of the HLA-DR gene product on adherent mono-nuclear cells and abnormalities in immune induction and the cytokine cascade.

Original languageEnglish (US)
Pages (from-to)138-141
Number of pages4
JournalThe Journal of Laboratory and Clinical Medicine
Volume108
Issue number2
StatePublished - 1986
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)
  • Pathology and Forensic Medicine

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