TY - JOUR
T1 - Immune Checkpoint Inhibitor Toxicity Review for the Palliative Care Clinician
AU - Hansen, Eric D.
AU - Wang, Xiao
AU - Case, Amy A.
AU - Puzanov, Igor
AU - Smith, Tom
N1 - Publisher Copyright:
© 2018 American Academy of Hospice and Palliative Medicine
PY - 2018/9
Y1 - 2018/9
N2 - Immune checkpoint inhibitors (ICIs) have opened an exciting chapter in the treatment of patients with advanced cancer. For the palliative care clinician, however, ICIs present several new challenges, including new ways to define treatment success, as well as treatment-related toxicities that differ in nature and timing from traditional chemotherapy. In this article, we review the mechanism of action of ICIs, as well as selected published data supporting the efficacy of ICIs in patients with advanced cancer. In addition, we summarize existing data of ICI toxicity prevalence, patterns of severity, and timing of onset. Finally, we briefly review key principles from published guidelines on the management of ICI toxicities.
AB - Immune checkpoint inhibitors (ICIs) have opened an exciting chapter in the treatment of patients with advanced cancer. For the palliative care clinician, however, ICIs present several new challenges, including new ways to define treatment success, as well as treatment-related toxicities that differ in nature and timing from traditional chemotherapy. In this article, we review the mechanism of action of ICIs, as well as selected published data supporting the efficacy of ICIs in patients with advanced cancer. In addition, we summarize existing data of ICI toxicity prevalence, patterns of severity, and timing of onset. Finally, we briefly review key principles from published guidelines on the management of ICI toxicities.
KW - Immunotherapy
KW - checkpoint inhibition
KW - immune-related adverse events
KW - toxicity
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U2 - 10.1016/j.jpainsymman.2018.05.015
DO - 10.1016/j.jpainsymman.2018.05.015
M3 - Article
C2 - 29792979
AN - SCOPUS:85049325324
VL - 56
SP - 460
EP - 472
JO - Journal of Pain and Symptom Management
JF - Journal of Pain and Symptom Management
SN - 0885-3924
IS - 3
ER -