Immune checkpoint inhibitor-induced sarcoidosis-like granulomas

Pooja H. Rambhia, Barbara Reichert, Jeffrey Scott, Ashley N. Feneran, Jordan A. Kazakov, Kord Honda, Henry Koon, Meg R. Gerstenblith

Research output: Contribution to journalReview article

Abstract

Immune checkpoint inhibitors targeting the cytotoxic T lymphocyte-associated antigen-4 and programmed cell death-1 receptors have transformed the treatment of melanoma and other cancers. These therapies are associated with a number of side effects, including immune-related adverse events. Sarcoidosis-like granulomas (SLGs) are important immune checkpoint inhibitor-related reactions to recognize as SLGs can mimic disease progression and accordingly impact treatment decisions. We systematically review reports of immune checkpoint inhibitor-induced SLGs in cancer patients and discuss potential underlying pathophysiological mechanisms.

Original languageEnglish (US)
JournalInternational Journal of Clinical Oncology
DOIs
StateAccepted/In press - Jan 1 2019
Externally publishedYes

Fingerprint

Sarcoidosis
Granuloma
Programmed Cell Death 1 Receptor
CTLA-4 Antigen
Disease Progression
Melanoma
Neoplasms
Therapeutics

Keywords

  • CTLA-4
  • Drug reactions
  • Immune checkpoint inhibitor
  • Melanoma
  • PD-1
  • Sarcoidosis-like granuloma

ASJC Scopus subject areas

  • Surgery
  • Hematology
  • Oncology

Cite this

Rambhia, P. H., Reichert, B., Scott, J., Feneran, A. N., Kazakov, J. A., Honda, K., ... Gerstenblith, M. R. (Accepted/In press). Immune checkpoint inhibitor-induced sarcoidosis-like granulomas. International Journal of Clinical Oncology. https://doi.org/10.1007/s10147-019-01490-2

Immune checkpoint inhibitor-induced sarcoidosis-like granulomas. / Rambhia, Pooja H.; Reichert, Barbara; Scott, Jeffrey; Feneran, Ashley N.; Kazakov, Jordan A.; Honda, Kord; Koon, Henry; Gerstenblith, Meg R.

In: International Journal of Clinical Oncology, 01.01.2019.

Research output: Contribution to journalReview article

Rambhia, Pooja H. ; Reichert, Barbara ; Scott, Jeffrey ; Feneran, Ashley N. ; Kazakov, Jordan A. ; Honda, Kord ; Koon, Henry ; Gerstenblith, Meg R. / Immune checkpoint inhibitor-induced sarcoidosis-like granulomas. In: International Journal of Clinical Oncology. 2019.
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