Immune checkpoint blockade in microsatellite instable colorectal cancers: Back to the clinic

Franck Housseau; Nicolas J. Llosa

doi:10.1080/2162402X.2015.1008858

Immune checkpoint blockade in microsatellite instable colorectal cancers: Back to the clinic

Franck Housseau, Nicolas J. Llosa

School of Medicine

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The active Th1/CTL immune microenvironment of Microsatellite Instable colorectal cancer (CRC) is counterbalanced by up-regulated expression of multiple immune checkpoints, suggesting that defective mismatch repair may be a biomarker to select CRC patients for treatment with checkpoint inhibitors. This hypothesis is currently being tested in two clinical trials.

Original language	English (US)
Journal	OncoImmunology
Volume	4
Issue number	6
DOIs	https://doi.org/10.1080/2162402X.2015.1008858
State	Published - Jan 1 2015

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Oncology

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10.1080/2162402X.2015.1008858

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title = "Immune checkpoint blockade in microsatellite instable colorectal cancers: Back to the clinic",

abstract = "The active Th1/CTL immune microenvironment of Microsatellite Instable colorectal cancer (CRC) is counterbalanced by up-regulated expression of multiple immune checkpoints, suggesting that defective mismatch repair may be a biomarker to select CRC patients for treatment with checkpoint inhibitors. This hypothesis is currently being tested in two clinical trials.",

author = "Franck Housseau and Llosa, {Nicolas J.}",

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AB - The active Th1/CTL immune microenvironment of Microsatellite Instable colorectal cancer (CRC) is counterbalanced by up-regulated expression of multiple immune checkpoints, suggesting that defective mismatch repair may be a biomarker to select CRC patients for treatment with checkpoint inhibitors. This hypothesis is currently being tested in two clinical trials.

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Immune checkpoint blockade in microsatellite instable colorectal cancers: Back to the clinic

Abstract

ASJC Scopus subject areas

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