Immune checkpoint blockade in microsatellite instable colorectal cancers: Back to the clinic

Franck Housseau, Nicolas J. Llosa

Research output: Contribution to journalArticlepeer-review

Abstract

The active Th1/CTL immune microenvironment of Microsatellite Instable colorectal cancer (CRC) is counterbalanced by up-regulated expression of multiple immune checkpoints, suggesting that defective mismatch repair may be a biomarker to select CRC patients for treatment with checkpoint inhibitors. This hypothesis is currently being tested in two clinical trials.

Original languageEnglish (US)
JournalOncoImmunology
Volume4
Issue number6
DOIs
StatePublished - Jan 1 2015

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology

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