TY - JOUR
T1 - Immune cell NT-3 expression is associated with brain atrophy in multiple sclerosis patients
AU - Kalinowska-Łyszczarz, Alicja
AU - Pawlak, Mikołaj A.
AU - Michalak, Sławomir
AU - Paprzycki, Włodzimierz
AU - Losy, Jacek
PY - 2011/12/15
Y1 - 2011/12/15
N2 - While neurotrophins mediate cell survival and proliferation in the nervous system, they are also expressed within peripheral blood mononuclear cells (PBMCs) of the immunological system. In multiple sclerosis (MS) neurotrophins released from PBMCs might play a neuroprotective role, delaying neurodegeneration within central nervous system. We aimed for identifying the link between neurotrophins' PBMCs expression and brain atrophy markers in relapsing-remitting MS (RRMS) patients. We have found that neurotrophin-3 PBMCs concentration is strongly correlated with brain-parenchymal fraction and corpus callosum cross-sectional area, which are well-established brain atrophy measures. Thus, PBMC-derived neurotrophin-3 might exert a direct or indirect neuroprotective effect in MS.
AB - While neurotrophins mediate cell survival and proliferation in the nervous system, they are also expressed within peripheral blood mononuclear cells (PBMCs) of the immunological system. In multiple sclerosis (MS) neurotrophins released from PBMCs might play a neuroprotective role, delaying neurodegeneration within central nervous system. We aimed for identifying the link between neurotrophins' PBMCs expression and brain atrophy markers in relapsing-remitting MS (RRMS) patients. We have found that neurotrophin-3 PBMCs concentration is strongly correlated with brain-parenchymal fraction and corpus callosum cross-sectional area, which are well-established brain atrophy measures. Thus, PBMC-derived neurotrophin-3 might exert a direct or indirect neuroprotective effect in MS.
KW - Brain atrophy
KW - Multiple sclerosis
KW - Neurotrophic factors
KW - Neurotrophin 3 (NT-3)
UR - http://www.scopus.com/inward/record.url?scp=83555177283&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=83555177283&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2011.10.002
DO - 10.1016/j.jneuroim.2011.10.002
M3 - Article
C2 - 22036954
AN - SCOPUS:83555177283
SN - 0165-5728
VL - 240-241
SP - 109
EP - 113
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
ER -