Immune cell infiltrates and prognosis in localized prostate cancer

Research output: Contribution to journalComment/debatepeer-review


Multiple lines of evidence indicate that quantification of immune cell infiltrates in primary prostate cancer can predict outcomes after radical prostatectomy, including biochemical recurrence, metastasis, and death from prostate cancer. In a recent issue of The Journal of Pathology, Andersen et al explored the predictive value of cancer tissue infiltration of seven immune cell types (mast cells, M1 macrophages, M2 macrophages, B cells, T helper cells, cytotoxic T cells, and regulatory T cells) in association with biochemical recurrence after radical prostatectomy. In addition to reporting a potential association between cancer-infiltrating regulatory T cells and M1 and M2 macrophages and biochemical recurrence, the study also highlighted the use of multiplex digital pathology analyses to assess adverse predictors of prostate cancer outcomes.

Original languageEnglish (US)
Pages (from-to)135-138
Number of pages4
JournalJournal of Pathology
Issue number2
StatePublished - Feb 2022

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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