Immune and Inflammatory Reponses to Staphylococcus aureus Skin Infections

Qi Liu, Momina Mazhar, Lloyd S. Miller

Research output: Contribution to journalReview articlepeer-review

Abstract

Purpose of Review: There have been recent advances in our understanding of cutaneous immune responses to the important human skin pathogen, Staphylococcus aureus (S. aureus). This review will highlight these insights into innate and adaptive immune mechanisms in host defense and cutaneous inflammation in response to S. aureus skin infections. Recent Findings: Antimicrobial peptides, pattern recognition receptors, and inflammasome activation function in innate immunity as well as T cells and their effector cytokines play a key role in adaptive immunity against S. aureus skin infections. In addition, certain mechanisms by which S. aureus contributes to aberrant cutaneous inflammation, such as in flares of the inflammatory skin disease atopic dermatitis, have also been identified. Summary: These cutaneous immune mechanisms could provide new targets for future vaccines and immune-based therapies to combat skin infections and cutaneous inflammation caused by S. aureus.

Original languageEnglish (US)
Pages (from-to)338-349
Number of pages12
JournalCurrent Dermatology Reports
Volume7
Issue number4
DOIs
StatePublished - Dec 1 2018

Keywords

  • Antimicrobial peptides
  • Inflammasome
  • Neutrophils
  • Staphylococcus aureus
  • T cells
  • Toll-like receptors

ASJC Scopus subject areas

  • Dermatology

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