Immune activation during measles

Interferon-γ and neopterin in plasma and cerebrospinal fluid in complicated and uncomplicated disease

Diane Griffin, Brian J. Ward, Enrique Jauregui, Richard Johnson, Abraham Vaisberg

Research output: Contribution to journalArticle

Abstract

To study T cell and macrophage activity during measles, levels of interferon-γ (IFN-γ) and neopterin in plasma and cerebrospinal fluid (CSF) were measured. Plasma levels of IFN-γ were elevated in measles (1.17 ± 0.27) compared with healthy adults (0.13 ± 0.06, P <.05) and children (0.14 ± 0.06, P <.01). Plasma levels of neopterin were elevated in measles (32.5 ± 2.7) compared with healthy adults (5.3 ± 2.9, P <.0001), healthy children (12.1 ± 4.0, P <.001), and children with other infectious diseases (20.6 ± 4.0, P <.02). IFN-γ was increased in measles primarily during rash; neopterin remained elevated for several weeks. Levels of neopterin showed a significant positive correlation with plasma levels of soluble interleukin-2 receptor and soluble CD8, two other parameters of T cell activation. Children with measles complicated by pneumonia had higher levels of neopterin in serum than those with uncomplicated disease. Children with measles complicated by autoimmune encephalomyelitis had higher levels of neopterin in CSF than those with noninflammatory neurologic disease but lower than those with central nervous system infections. Thus, IFN-γ seems to be produced in vivo during acute measles virus infection; deficiency of this lymphokine does not appear to correlate with increased susceptibility to secondary infections.

Original languageEnglish (US)
Pages (from-to)449-453
Number of pages5
JournalJournal of Infectious Diseases
Volume161
Issue number3
StatePublished - Mar 1990

Fingerprint

Neopterin
Measles
Interferons
Cerebrospinal Fluid
T-Lymphocytes
Encephalomyelitis
Central Nervous System Infections
Measles virus
Interleukin-2 Receptors
Virus Diseases
Exanthema
Nervous System Diseases
Coinfection
Communicable Diseases
Pneumonia
Macrophages
Serum

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Immune activation during measles : Interferon-γ and neopterin in plasma and cerebrospinal fluid in complicated and uncomplicated disease. / Griffin, Diane; Ward, Brian J.; Jauregui, Enrique; Johnson, Richard; Vaisberg, Abraham.

In: Journal of Infectious Diseases, Vol. 161, No. 3, 03.1990, p. 449-453.

Research output: Contribution to journalArticle

@article{a8ece30b24ab4133b5a3457bdf1b4be3,
title = "Immune activation during measles: Interferon-γ and neopterin in plasma and cerebrospinal fluid in complicated and uncomplicated disease",
abstract = "To study T cell and macrophage activity during measles, levels of interferon-γ (IFN-γ) and neopterin in plasma and cerebrospinal fluid (CSF) were measured. Plasma levels of IFN-γ were elevated in measles (1.17 ± 0.27) compared with healthy adults (0.13 ± 0.06, P <.05) and children (0.14 ± 0.06, P <.01). Plasma levels of neopterin were elevated in measles (32.5 ± 2.7) compared with healthy adults (5.3 ± 2.9, P <.0001), healthy children (12.1 ± 4.0, P <.001), and children with other infectious diseases (20.6 ± 4.0, P <.02). IFN-γ was increased in measles primarily during rash; neopterin remained elevated for several weeks. Levels of neopterin showed a significant positive correlation with plasma levels of soluble interleukin-2 receptor and soluble CD8, two other parameters of T cell activation. Children with measles complicated by pneumonia had higher levels of neopterin in serum than those with uncomplicated disease. Children with measles complicated by autoimmune encephalomyelitis had higher levels of neopterin in CSF than those with noninflammatory neurologic disease but lower than those with central nervous system infections. Thus, IFN-γ seems to be produced in vivo during acute measles virus infection; deficiency of this lymphokine does not appear to correlate with increased susceptibility to secondary infections.",
author = "Diane Griffin and Ward, {Brian J.} and Enrique Jauregui and Richard Johnson and Abraham Vaisberg",
year = "1990",
month = "3",
language = "English (US)",
volume = "161",
pages = "449--453",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "3",

}

TY - JOUR

T1 - Immune activation during measles

T2 - Interferon-γ and neopterin in plasma and cerebrospinal fluid in complicated and uncomplicated disease

AU - Griffin, Diane

AU - Ward, Brian J.

AU - Jauregui, Enrique

AU - Johnson, Richard

AU - Vaisberg, Abraham

PY - 1990/3

Y1 - 1990/3

N2 - To study T cell and macrophage activity during measles, levels of interferon-γ (IFN-γ) and neopterin in plasma and cerebrospinal fluid (CSF) were measured. Plasma levels of IFN-γ were elevated in measles (1.17 ± 0.27) compared with healthy adults (0.13 ± 0.06, P <.05) and children (0.14 ± 0.06, P <.01). Plasma levels of neopterin were elevated in measles (32.5 ± 2.7) compared with healthy adults (5.3 ± 2.9, P <.0001), healthy children (12.1 ± 4.0, P <.001), and children with other infectious diseases (20.6 ± 4.0, P <.02). IFN-γ was increased in measles primarily during rash; neopterin remained elevated for several weeks. Levels of neopterin showed a significant positive correlation with plasma levels of soluble interleukin-2 receptor and soluble CD8, two other parameters of T cell activation. Children with measles complicated by pneumonia had higher levels of neopterin in serum than those with uncomplicated disease. Children with measles complicated by autoimmune encephalomyelitis had higher levels of neopterin in CSF than those with noninflammatory neurologic disease but lower than those with central nervous system infections. Thus, IFN-γ seems to be produced in vivo during acute measles virus infection; deficiency of this lymphokine does not appear to correlate with increased susceptibility to secondary infections.

AB - To study T cell and macrophage activity during measles, levels of interferon-γ (IFN-γ) and neopterin in plasma and cerebrospinal fluid (CSF) were measured. Plasma levels of IFN-γ were elevated in measles (1.17 ± 0.27) compared with healthy adults (0.13 ± 0.06, P <.05) and children (0.14 ± 0.06, P <.01). Plasma levels of neopterin were elevated in measles (32.5 ± 2.7) compared with healthy adults (5.3 ± 2.9, P <.0001), healthy children (12.1 ± 4.0, P <.001), and children with other infectious diseases (20.6 ± 4.0, P <.02). IFN-γ was increased in measles primarily during rash; neopterin remained elevated for several weeks. Levels of neopterin showed a significant positive correlation with plasma levels of soluble interleukin-2 receptor and soluble CD8, two other parameters of T cell activation. Children with measles complicated by pneumonia had higher levels of neopterin in serum than those with uncomplicated disease. Children with measles complicated by autoimmune encephalomyelitis had higher levels of neopterin in CSF than those with noninflammatory neurologic disease but lower than those with central nervous system infections. Thus, IFN-γ seems to be produced in vivo during acute measles virus infection; deficiency of this lymphokine does not appear to correlate with increased susceptibility to secondary infections.

UR - http://www.scopus.com/inward/record.url?scp=0025259873&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025259873&partnerID=8YFLogxK

M3 - Article

VL - 161

SP - 449

EP - 453

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 3

ER -