TY - JOUR
T1 - Immune activation during measles
T2 - Interferon-γ and neopterin in plasma and cerebrospinal fluid in complicated and uncomplicated disease
AU - Griffin, Diane E.
AU - Ward, Brian J.
AU - Jauregui, Enrique
AU - Johnson, Richard T.
AU - Vaisberg, Abraham
N1 - Funding Information:
Received 15 May 1989; revised 2 October 1989. Grant support: National Multiple Sclerosis Society and National Institutes of Health (AI-23047). Reprints and correspondence: Dr. Diane E. Griffin, Dept. of Neurology, The Johns Hopkins Hospital, Meyer Bldg., Room 6-181,600 N. Wolfe St., Baltimore, MD 21205.
Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1990/3
Y1 - 1990/3
N2 - To study T cell and macrophage activity during measles, levels of interferon-γ (IFN-γ) and neopterin in plasma and cerebrospinal fluid (CSF) were measured. Plasma levels of IFN-γ were elevated in measles (1.17 ±0.27)compared with healthy adults (0.13 ± 0.06, P<.05)and children (0.14 ± 0.06, P <.01).Plasma levelsof neopterin were elevated in measles (32.5 ± 2.7) compared with healthy adults (5.3 ± 2.9, P <.0001), healthy children (12.1 ± 4.0, P <.001), and children with other infectious diseases (20.6 ± 4.0, P <.02). IFN-γ was increased in measles primarily during rash; neopterln remained elevatedfor several weeks. Levels of neopterln showed a significant positive correlation with plasma levels of soluble interleukin-2 receptor and soluble CDS, two other parameters of T cell activation. Children with measles complicated by pneumonia had higher levels of neopterin in serum than those with uncomplicated disease. Children with measles complicated by autoimmune encephalomyelitis had higher levels of neopterin in CSF than those with noninflammatory neurologic disease but lower than those with central nervous system infections. Thus, IFN-γ seems to be produced in vivo during acute measles virus infection; deficiency of this Iymphokine does not appear to correlate with increased susceptibility to secondary infections.
AB - To study T cell and macrophage activity during measles, levels of interferon-γ (IFN-γ) and neopterin in plasma and cerebrospinal fluid (CSF) were measured. Plasma levels of IFN-γ were elevated in measles (1.17 ±0.27)compared with healthy adults (0.13 ± 0.06, P<.05)and children (0.14 ± 0.06, P <.01).Plasma levelsof neopterin were elevated in measles (32.5 ± 2.7) compared with healthy adults (5.3 ± 2.9, P <.0001), healthy children (12.1 ± 4.0, P <.001), and children with other infectious diseases (20.6 ± 4.0, P <.02). IFN-γ was increased in measles primarily during rash; neopterln remained elevatedfor several weeks. Levels of neopterln showed a significant positive correlation with plasma levels of soluble interleukin-2 receptor and soluble CDS, two other parameters of T cell activation. Children with measles complicated by pneumonia had higher levels of neopterin in serum than those with uncomplicated disease. Children with measles complicated by autoimmune encephalomyelitis had higher levels of neopterin in CSF than those with noninflammatory neurologic disease but lower than those with central nervous system infections. Thus, IFN-γ seems to be produced in vivo during acute measles virus infection; deficiency of this Iymphokine does not appear to correlate with increased susceptibility to secondary infections.
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U2 - 10.1093/infdis/161.3.449
DO - 10.1093/infdis/161.3.449
M3 - Article
C2 - 2107264
AN - SCOPUS:0025259873
SN - 0022-1899
VL - 161
SP - 449
EP - 453
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 3
ER -