Immediate-early proteins of human cytomegalovirus strains AD169, Davis, and towne differ in electrophoretic mobility

Research output: Contribution to journalArticle

Abstract

Electrophoretic comparisons of the immediate-early (IE) proteins of three strains of cytomegalovirus (CMV) isolated from adenoidal tissue (Ad169), liver (Davis), and urine (Towne) of humans, have shown that they are distinguishable. Experiments based on "pulse-chase" radiolabeling, biosynthetic phosphorylation, and in vitro protein synthesis indicate that these differences are not the consequence of slow post-translational modification. Results of a comparison of high- and low-passage stocks of Towne virus suggest that these mobility differences reflect natural variation, rather than alterations resulting from propagation in tissue culture.

Original languageEnglish (US)
Pages (from-to)350-354
Number of pages5
JournalVirology
Volume112
Issue number1
DOIs
StatePublished - Jul 15 1981

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Immediate-Early Proteins
Post Translational Protein Processing
Cytomegalovirus
Phosphorylation
Urine
Viruses
Liver
Proteins
cytomegalovirus immediate-early proteins
In Vitro Techniques

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Immediate-early proteins of human cytomegalovirus strains AD169, Davis, and towne differ in electrophoretic mobility. / Gibson, D Wade.

In: Virology, Vol. 112, No. 1, 15.07.1981, p. 350-354.

Research output: Contribution to journalArticle

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