TY - JOUR
T1 - Immediate-early proteins of human cytomegalovirus strains AD169, Davis, and towne differ in electrophoretic mobility
AU - Gibson, Wade
N1 - Funding Information:
I thank Dr. Stanley Plotkin of the Wistar Institute for the Towne strains used in this study and Michael Murphy for excellent technical assistance. This work was aided by Grants AI13718 and AI16959 from the National Institute for Allergy and Infectious Diseases, and Grant 1-613 from the National Foundation for Birth Defects.
Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1981/7/15
Y1 - 1981/7/15
N2 - Electrophoretic comparisons of the immediate-early (IE) proteins of three strains of cytomegalovirus (CMV) isolated from adenoidal tissue (Ad169), liver (Davis), and urine (Towne) of humans, have shown that they are distinguishable. Experiments based on "pulse-chase" radiolabeling, biosynthetic phosphorylation, and in vitro protein synthesis indicate that these differences are not the consequence of slow post-translational modification. Results of a comparison of high- and low-passage stocks of Towne virus suggest that these mobility differences reflect natural variation, rather than alterations resulting from propagation in tissue culture.
AB - Electrophoretic comparisons of the immediate-early (IE) proteins of three strains of cytomegalovirus (CMV) isolated from adenoidal tissue (Ad169), liver (Davis), and urine (Towne) of humans, have shown that they are distinguishable. Experiments based on "pulse-chase" radiolabeling, biosynthetic phosphorylation, and in vitro protein synthesis indicate that these differences are not the consequence of slow post-translational modification. Results of a comparison of high- and low-passage stocks of Towne virus suggest that these mobility differences reflect natural variation, rather than alterations resulting from propagation in tissue culture.
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U2 - 10.1016/0042-6822(81)90641-3
DO - 10.1016/0042-6822(81)90641-3
M3 - Article
C2 - 6264690
AN - SCOPUS:0019418738
SN - 0042-6822
VL - 112
SP - 350
EP - 354
JO - Virology
JF - Virology
IS - 1
ER -