TY - JOUR
T1 - Imipramine and Chlordiazepoxide in Depressive and Anxiety Disorders
T2 - I. Efficacy in Depressed Outpatients
AU - Lipman, Ronald S.
AU - Covi, Lino
AU - Rickels, Karl
AU - McNair, Douglas M.
AU - Downing, Robert
AU - Kahn, Richard J.
AU - Lasseter, Virginia K.
AU - Faden, Vivian
PY - 1986/1
Y1 - 1986/1
N2 - We randomly assigned 425 outpatients, independently classified as primarily depressed by two trained psychiatrists, to double-blind treatment with imipramine hydrochloride, chlordiazepoxide hydrochloride, or placebo. Those patients who remained at least moderately depressed (following a twoweek placebo washout period) were treated for an additional eight weeks. An endpoint analysis of 387 patients who completed two or more weeks of medication disclosed early therapeutic advantages of chlordiazepoxide. By week 4 of treatment, however, imipramine produced more improvement than did placebo and chlordiazepoxide. By six and eight weeks a general, marked therapeutic advantage was found for imipramine relative to placebo and to chlordiazepoxide on measures of depression, anxiety, anger-hostility, interpersonal sensitivity, and global improvement. Chlordiazepoxide-treated patients generally did significantly better on sleep difficulty but significantly worse on anger-hostility and interpersonal sensitivity than did imipramine- or placebo-treated patients.
AB - We randomly assigned 425 outpatients, independently classified as primarily depressed by two trained psychiatrists, to double-blind treatment with imipramine hydrochloride, chlordiazepoxide hydrochloride, or placebo. Those patients who remained at least moderately depressed (following a twoweek placebo washout period) were treated for an additional eight weeks. An endpoint analysis of 387 patients who completed two or more weeks of medication disclosed early therapeutic advantages of chlordiazepoxide. By week 4 of treatment, however, imipramine produced more improvement than did placebo and chlordiazepoxide. By six and eight weeks a general, marked therapeutic advantage was found for imipramine relative to placebo and to chlordiazepoxide on measures of depression, anxiety, anger-hostility, interpersonal sensitivity, and global improvement. Chlordiazepoxide-treated patients generally did significantly better on sleep difficulty but significantly worse on anger-hostility and interpersonal sensitivity than did imipramine- or placebo-treated patients.
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U2 - 10.1001/archpsyc.1986.01800010070009
DO - 10.1001/archpsyc.1986.01800010070009
M3 - Article
C2 - 3510601
AN - SCOPUS:0022573297
SN - 0003-990X
VL - 43
SP - 68
EP - 77
JO - Archives of general psychiatry
JF - Archives of general psychiatry
IS - 1
ER -