Imipenem/cilastatin treatment of bacterial meningitis in children

Victor K. Wong, Harry T. Wright, Lawrence A. Ross, Wilbert H. Mason, Clark B. Inderlied, Kwang Sik Kim

Research output: Contribution to journalArticlepeer-review

Abstract

The safety and efficacy of imipenem/cilastatin were evaluated in 21 children, ages 3 to 48 months, with bacterial meningitis. Eradication of bacteria from the cerebrospinal fluid was demonstrated within 24 hours of antibiotic therapy in all but 2 patients who had Haemophilus influenzae type b meningitis and ultimately achieved bacteriologic cure after 2 to 3 days of imipenem/cilastatin therapy. Cerebrospinal fluid penetrations of imipenem and cilastatin were determined at various times after drug administration with mean cerebrospinal fluid: serum ratios of 14 and 10% for imipenem and cilastatin, respectively. The study was terminated when 7 (33%) patients developed seizure activity after antibiotic therapy was administered. The usefulness of imipenem/cilastatin for the treatment of bacterial meningitis in children may be limited by a possible increased incidence of drug-related seizure activity.

Original languageEnglish (US)
Pages (from-to)122-125
Number of pages4
JournalPediatric Infectious Disease Journal
Volume10
Issue number2
DOIs
StatePublished - Feb 1991
Externally publishedYes

Keywords

  • Bacterial meningitis
  • Imipenem/cilastatin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Imipenem/cilastatin treatment of bacterial meningitis in children'. Together they form a unique fingerprint.

Cite this