Abstract
Magnetic resonance imaging (MRI) has led to the identification of widespread brain abnormalities in multiple sclerosis (MS) that extend far beyond the classic white matter lesion. These findings have generated the idea that MS should be understood as a disease of the whole brain, not just the white matter. While it is no doubt the case that many different pathways are ultimately involved in the destruction of brain tissue that occurs in MS, the implications of the accumulated evidence for understanding disease pathophysiology - and hence the overall significance of these imaging findings - are doubtful. Here, I argue that the principled use of imaging can, in fact, address questions about the genesis of these whole-brain abnormalities, rather than simply describe them.
| Original language | English (US) |
|---|---|
| Journal | Journal of Neuroimmunology |
| DOIs | |
| State | Accepted/In press - Oct 20 2015 |
| Externally published | Yes |
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Keywords
- Magnetic resonance imaging
- Multiple sclerosis
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Neurology
- Clinical Neurology
Cite this
Imag(in)ing multiple sclerosis : Time to take better pictures. / Reich, Daniel S.
In: Journal of Neuroimmunology, 20.10.2015.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Imag(in)ing multiple sclerosis
T2 - Time to take better pictures
AU - Reich, Daniel S.
PY - 2015/10/20
Y1 - 2015/10/20
N2 - Magnetic resonance imaging (MRI) has led to the identification of widespread brain abnormalities in multiple sclerosis (MS) that extend far beyond the classic white matter lesion. These findings have generated the idea that MS should be understood as a disease of the whole brain, not just the white matter. While it is no doubt the case that many different pathways are ultimately involved in the destruction of brain tissue that occurs in MS, the implications of the accumulated evidence for understanding disease pathophysiology - and hence the overall significance of these imaging findings - are doubtful. Here, I argue that the principled use of imaging can, in fact, address questions about the genesis of these whole-brain abnormalities, rather than simply describe them.
AB - Magnetic resonance imaging (MRI) has led to the identification of widespread brain abnormalities in multiple sclerosis (MS) that extend far beyond the classic white matter lesion. These findings have generated the idea that MS should be understood as a disease of the whole brain, not just the white matter. While it is no doubt the case that many different pathways are ultimately involved in the destruction of brain tissue that occurs in MS, the implications of the accumulated evidence for understanding disease pathophysiology - and hence the overall significance of these imaging findings - are doubtful. Here, I argue that the principled use of imaging can, in fact, address questions about the genesis of these whole-brain abnormalities, rather than simply describe them.
KW - Magnetic resonance imaging
KW - Multiple sclerosis
UR - http://www.scopus.com/inward/record.url?scp=85002412680&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85002412680&partnerID=8YFLogxK
U2 - 10.1016/j.jneuroim.2016.09.015
DO - 10.1016/j.jneuroim.2016.09.015
M3 - Article
C2 - 27742080
AN - SCOPUS:85002412680
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
ER -