Imaging virus-associated cancer

Research output: Contribution to journalReview articlepeer-review

Abstract

Cancer remains an important and growing health problem. Researchers have made great progress in defining genetic and molecular alterations that contribute to cancer formation and progression. Molecular imaging can identify appropriate patients for targeted cancer therapy and may detect early biochemical changes in tumors during therapy, some of which may have important prognostic implications. Progress in this field continues largely due to a union between molecular genetics and advanced imaging technology. This review details uses of molecular-genetic imaging in the context of tumor-associated viruses. Under certain conditions, and particularly during pharmacologic stimulation, gammaherpesviruses will express genes that enable imaging and therapy in vivo. The techniques discussed are readily translatable to the clinic.

Original languageEnglish (US)
Pages (from-to)3048-3065
Number of pages18
JournalCurrent pharmaceutical design
Volume14
Issue number28
DOIs
StatePublished - Oct 2008

Keywords

  • Bortezomib
  • EBV
  • FIAU
  • Molecular imaging
  • Thymidine kinase

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

Fingerprint Dive into the research topics of 'Imaging virus-associated cancer'. Together they form a unique fingerprint.

Cite this