Imaging virus-associated cancer

Research output: Contribution to journalArticle

Abstract

Cancer remains an important and growing health problem. Researchers have made great progress in defining genetic and molecular alterations that contribute to cancer formation and progression. Molecular imaging can identify appropriate patients for targeted cancer therapy and may detect early biochemical changes in tumors during therapy, some of which may have important prognostic implications. Progress in this field continues largely due to a union between molecular genetics and advanced imaging technology. This review details uses of molecular-genetic imaging in the context of tumor-associated viruses. Under certain conditions, and particularly during pharmacologic stimulation, gammaherpesviruses will express genes that enable imaging and therapy in vivo. The techniques discussed are readily translatable to the clinic.

Original languageEnglish (US)
Pages (from-to)3048-3065
Number of pages18
JournalCurrent Pharmaceutical Design
Volume14
Issue number28
DOIs
StatePublished - Oct 2008

Fingerprint

Viruses
Molecular Biology
Molecular Imaging
Neoplasms
Satellite Viruses
Oncogenic Viruses
Therapeutics
Research Personnel
Technology
Health
Genes

Keywords

  • Bortezomib
  • EBV
  • FIAU
  • Molecular imaging
  • Thymidine kinase

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

Cite this

Imaging virus-associated cancer. / Fu, De Xue; Foss, Catherine; Nimmagadda, Sridhar; Ambinder, Richard F; Pomper, Martin Gilbert.

In: Current Pharmaceutical Design, Vol. 14, No. 28, 10.2008, p. 3048-3065.

Research output: Contribution to journalArticle

@article{ce7a3829b6174e0e9ead902751552152,
title = "Imaging virus-associated cancer",
abstract = "Cancer remains an important and growing health problem. Researchers have made great progress in defining genetic and molecular alterations that contribute to cancer formation and progression. Molecular imaging can identify appropriate patients for targeted cancer therapy and may detect early biochemical changes in tumors during therapy, some of which may have important prognostic implications. Progress in this field continues largely due to a union between molecular genetics and advanced imaging technology. This review details uses of molecular-genetic imaging in the context of tumor-associated viruses. Under certain conditions, and particularly during pharmacologic stimulation, gammaherpesviruses will express genes that enable imaging and therapy in vivo. The techniques discussed are readily translatable to the clinic.",
keywords = "Bortezomib, EBV, FIAU, Molecular imaging, Thymidine kinase",
author = "Fu, {De Xue} and Catherine Foss and Sridhar Nimmagadda and Ambinder, {Richard F} and Pomper, {Martin Gilbert}",
year = "2008",
month = "10",
doi = "10.2174/138161208786404371",
language = "English (US)",
volume = "14",
pages = "3048--3065",
journal = "Current Pharmaceutical Design",
issn = "1381-6128",
publisher = "Bentham Science Publishers B.V.",
number = "28",

}

TY - JOUR

T1 - Imaging virus-associated cancer

AU - Fu, De Xue

AU - Foss, Catherine

AU - Nimmagadda, Sridhar

AU - Ambinder, Richard F

AU - Pomper, Martin Gilbert

PY - 2008/10

Y1 - 2008/10

N2 - Cancer remains an important and growing health problem. Researchers have made great progress in defining genetic and molecular alterations that contribute to cancer formation and progression. Molecular imaging can identify appropriate patients for targeted cancer therapy and may detect early biochemical changes in tumors during therapy, some of which may have important prognostic implications. Progress in this field continues largely due to a union between molecular genetics and advanced imaging technology. This review details uses of molecular-genetic imaging in the context of tumor-associated viruses. Under certain conditions, and particularly during pharmacologic stimulation, gammaherpesviruses will express genes that enable imaging and therapy in vivo. The techniques discussed are readily translatable to the clinic.

AB - Cancer remains an important and growing health problem. Researchers have made great progress in defining genetic and molecular alterations that contribute to cancer formation and progression. Molecular imaging can identify appropriate patients for targeted cancer therapy and may detect early biochemical changes in tumors during therapy, some of which may have important prognostic implications. Progress in this field continues largely due to a union between molecular genetics and advanced imaging technology. This review details uses of molecular-genetic imaging in the context of tumor-associated viruses. Under certain conditions, and particularly during pharmacologic stimulation, gammaherpesviruses will express genes that enable imaging and therapy in vivo. The techniques discussed are readily translatable to the clinic.

KW - Bortezomib

KW - EBV

KW - FIAU

KW - Molecular imaging

KW - Thymidine kinase

UR - http://www.scopus.com/inward/record.url?scp=58149382049&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=58149382049&partnerID=8YFLogxK

U2 - 10.2174/138161208786404371

DO - 10.2174/138161208786404371

M3 - Article

VL - 14

SP - 3048

EP - 3065

JO - Current Pharmaceutical Design

JF - Current Pharmaceutical Design

SN - 1381-6128

IS - 28

ER -