TY - JOUR
T1 - Imaging the cerebral blood flow with enhanced laser speckle contrast analysis (eLASCA) by monotonic point transformation
AU - Miao, Peng
AU - Li, Minheng
AU - Fontenelle, Hugues
AU - Bezerianos, Anastasios
AU - Qiu, Yihong
AU - Tong, Shanbao
N1 - Funding Information:
Manuscript received April 8, 2008; revised August 4, 2008. First published October 31, 2008; current version published May 6, 2009. This work was supported in part by the Shanghai Pujiang Program under Grant 06PJ14055 and by the University of Patras, Karatheodoris, under Grant 2004-B411. The work of S. Tong was supported by the Program for New Century Excellent Talents. Asterisk indicates corresponding author.
PY - 2009/4
Y1 - 2009/4
N2 - Laser speckle contrast analysis (LASCA) has been demonstrated as a full-field method for imaging the cerebral blood flow (CBF). However, conventional LASCA is limited to extremely low dynamic range because of the ambient background field, dark current, and other anomalies in the circuits of a charge-coupled device camera, which makes it difficult to analyze the spatiotemporal variabilities in CBF. In this study, we proposed an enhanced LASCA (eLASCA) method to improve the dynamic range of LASCA based on monotonic point transformation. In investigating the influence of moderate hypothermia 32 ±0.5 C°) on capillary CBF change, eLASCA presented much more significant decrease of relative CBF than LASCA (hypothermia: 189% versus 137%, postrewarming: 151% versus 119%). Statistically, eLASCA resulted in a higher confidence degree ( p=0.009) of CBF change after the rewarming than LASCA ( p=0.013). In addition, eLASCA greatly improves the CBF visualization, which is very helpful in demonstrating the details of CBF change.
AB - Laser speckle contrast analysis (LASCA) has been demonstrated as a full-field method for imaging the cerebral blood flow (CBF). However, conventional LASCA is limited to extremely low dynamic range because of the ambient background field, dark current, and other anomalies in the circuits of a charge-coupled device camera, which makes it difficult to analyze the spatiotemporal variabilities in CBF. In this study, we proposed an enhanced LASCA (eLASCA) method to improve the dynamic range of LASCA based on monotonic point transformation. In investigating the influence of moderate hypothermia 32 ±0.5 C°) on capillary CBF change, eLASCA presented much more significant decrease of relative CBF than LASCA (hypothermia: 189% versus 137%, postrewarming: 151% versus 119%). Statistically, eLASCA resulted in a higher confidence degree ( p=0.009) of CBF change after the rewarming than LASCA ( p=0.013). In addition, eLASCA greatly improves the CBF visualization, which is very helpful in demonstrating the details of CBF change.
KW - Cerebral blood flow (CBF)
KW - Dynamic range enhancement
KW - Hypothermia
KW - Laser speckle contrast analysis (LASCA)
KW - Monotonic point transformation (MPT)
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U2 - 10.1109/TBME.2008.2006855
DO - 10.1109/TBME.2008.2006855
M3 - Article
C2 - 19272894
AN - SCOPUS:67149123570
SN - 0018-9294
VL - 56
SP - 1127
EP - 1133
JO - IEEE Transactions on Biomedical Engineering
JF - IEEE Transactions on Biomedical Engineering
IS - 4
M1 - 4663621
ER -