Imaging outcome measures of neuroprotection and repair in MS

A consensus statement from NAIMS

Jiwon Oh, Daniel Ontaneda, Christina Azevedo, Eric C. Klawiter, Martina Absinta, Douglas L. Arnold, Rohit Bakshi, Peter Calabresi, Ciprian M Crainiceanu, Blake Dewey, Leorah Freeman, Susan Gauthier, Roland Henry, Mathilde Inglese, Shannon Kolind, David K.B. Li, Caterina Mainero, Ravi S. Menon, Govind Nair, Sridar Narayanan & 15 others Flavia Nelson, Daniel Pelletier, Alexander Rauscher, William Rooney, Pascal Sati, Daniel Schwartz, Russell T. Shinohara, Ian Tagge, Anthony Traboulsee, Yi Wang, Youngjin Yoo, Tarek Yousry, Yunyan Zhang, Nancy L. Sicotte, Daniel S. Reich

Research output: Contribution to journalReview article

Abstract

To summarize current and emerging imaging techniques that can be used to assess neuroprotection and repair in multiple sclerosis (MS), and to provide a consensus opinion on the potential utility of each technique in clinical trial settings.MethodsClinicians and scientists with expertise in the use of MRI in MS convened in Toronto, Canada, in November 2016 at a North American Imaging in Multiple Sclerosis (NAIMS) Cooperative workshop meeting. The discussion was compiled into a manuscript and circulated to all NAIMS members in attendance. Edits and feedback were incorporated until all authors were in agreement.ResultsA wide spectrum of imaging techniques and analysis methods in the context of specific study designs were discussed, with a focus on the utility and limitations of applying each technique to assess neuroprotection and repair. Techniques were discussed under specific themes, and included conventional imaging, magnetization transfer ratio, diffusion tensor imaging, susceptibility-weighted imaging, imaging cortical lesions, magnetic resonance spectroscopy, PET, advanced diffusion imaging, sodium imaging, multimodal techniques, imaging of special regions, statistical considerations, and study design.ConclusionsImaging biomarkers of neuroprotection and repair are an unmet need in MS. There are a number of promising techniques with different strengths and limitations, and selection of a specific technique will depend on a number of factors, notably the question the trial seeks to answer. Ongoing collaborative efforts will enable further refinement and improved methods to image the effect of novel therapeutic agents that exert benefit in MS predominately through neuroprotective and reparative mechanisms.

Original languageEnglish (US)
Pages (from-to)519-533
Number of pages15
JournalNeurology
Volume92
Issue number11
DOIs
StatePublished - Mar 12 2019

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Multiple Sclerosis
Outcome Assessment (Health Care)
Multimodal Imaging
Diffusion Tensor Imaging
Manuscripts
Therapeutic Uses
Canada
Neuroprotection
Magnetic Resonance Spectroscopy
Biomarkers
Sodium
Clinical Trials
Education

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Oh, J., Ontaneda, D., Azevedo, C., Klawiter, E. C., Absinta, M., Arnold, D. L., ... Reich, D. S. (2019). Imaging outcome measures of neuroprotection and repair in MS: A consensus statement from NAIMS. Neurology, 92(11), 519-533. https://doi.org/10.1212/WNL.0000000000007099

Imaging outcome measures of neuroprotection and repair in MS : A consensus statement from NAIMS. / Oh, Jiwon; Ontaneda, Daniel; Azevedo, Christina; Klawiter, Eric C.; Absinta, Martina; Arnold, Douglas L.; Bakshi, Rohit; Calabresi, Peter; Crainiceanu, Ciprian M; Dewey, Blake; Freeman, Leorah; Gauthier, Susan; Henry, Roland; Inglese, Mathilde; Kolind, Shannon; Li, David K.B.; Mainero, Caterina; Menon, Ravi S.; Nair, Govind; Narayanan, Sridar; Nelson, Flavia; Pelletier, Daniel; Rauscher, Alexander; Rooney, William; Sati, Pascal; Schwartz, Daniel; Shinohara, Russell T.; Tagge, Ian; Traboulsee, Anthony; Wang, Yi; Yoo, Youngjin; Yousry, Tarek; Zhang, Yunyan; Sicotte, Nancy L.; Reich, Daniel S.

In: Neurology, Vol. 92, No. 11, 12.03.2019, p. 519-533.

Research output: Contribution to journalReview article

Oh, J, Ontaneda, D, Azevedo, C, Klawiter, EC, Absinta, M, Arnold, DL, Bakshi, R, Calabresi, P, Crainiceanu, CM, Dewey, B, Freeman, L, Gauthier, S, Henry, R, Inglese, M, Kolind, S, Li, DKB, Mainero, C, Menon, RS, Nair, G, Narayanan, S, Nelson, F, Pelletier, D, Rauscher, A, Rooney, W, Sati, P, Schwartz, D, Shinohara, RT, Tagge, I, Traboulsee, A, Wang, Y, Yoo, Y, Yousry, T, Zhang, Y, Sicotte, NL & Reich, DS 2019, 'Imaging outcome measures of neuroprotection and repair in MS: A consensus statement from NAIMS', Neurology, vol. 92, no. 11, pp. 519-533. https://doi.org/10.1212/WNL.0000000000007099
Oh, Jiwon ; Ontaneda, Daniel ; Azevedo, Christina ; Klawiter, Eric C. ; Absinta, Martina ; Arnold, Douglas L. ; Bakshi, Rohit ; Calabresi, Peter ; Crainiceanu, Ciprian M ; Dewey, Blake ; Freeman, Leorah ; Gauthier, Susan ; Henry, Roland ; Inglese, Mathilde ; Kolind, Shannon ; Li, David K.B. ; Mainero, Caterina ; Menon, Ravi S. ; Nair, Govind ; Narayanan, Sridar ; Nelson, Flavia ; Pelletier, Daniel ; Rauscher, Alexander ; Rooney, William ; Sati, Pascal ; Schwartz, Daniel ; Shinohara, Russell T. ; Tagge, Ian ; Traboulsee, Anthony ; Wang, Yi ; Yoo, Youngjin ; Yousry, Tarek ; Zhang, Yunyan ; Sicotte, Nancy L. ; Reich, Daniel S. / Imaging outcome measures of neuroprotection and repair in MS : A consensus statement from NAIMS. In: Neurology. 2019 ; Vol. 92, No. 11. pp. 519-533.
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abstract = "To summarize current and emerging imaging techniques that can be used to assess neuroprotection and repair in multiple sclerosis (MS), and to provide a consensus opinion on the potential utility of each technique in clinical trial settings.MethodsClinicians and scientists with expertise in the use of MRI in MS convened in Toronto, Canada, in November 2016 at a North American Imaging in Multiple Sclerosis (NAIMS) Cooperative workshop meeting. The discussion was compiled into a manuscript and circulated to all NAIMS members in attendance. Edits and feedback were incorporated until all authors were in agreement.ResultsA wide spectrum of imaging techniques and analysis methods in the context of specific study designs were discussed, with a focus on the utility and limitations of applying each technique to assess neuroprotection and repair. Techniques were discussed under specific themes, and included conventional imaging, magnetization transfer ratio, diffusion tensor imaging, susceptibility-weighted imaging, imaging cortical lesions, magnetic resonance spectroscopy, PET, advanced diffusion imaging, sodium imaging, multimodal techniques, imaging of special regions, statistical considerations, and study design.ConclusionsImaging biomarkers of neuroprotection and repair are an unmet need in MS. There are a number of promising techniques with different strengths and limitations, and selection of a specific technique will depend on a number of factors, notably the question the trial seeks to answer. Ongoing collaborative efforts will enable further refinement and improved methods to image the effect of novel therapeutic agents that exert benefit in MS predominately through neuroprotective and reparative mechanisms.",
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T1 - Imaging outcome measures of neuroprotection and repair in MS

T2 - A consensus statement from NAIMS

AU - Oh, Jiwon

AU - Ontaneda, Daniel

AU - Azevedo, Christina

AU - Klawiter, Eric C.

AU - Absinta, Martina

AU - Arnold, Douglas L.

AU - Bakshi, Rohit

AU - Calabresi, Peter

AU - Crainiceanu, Ciprian M

AU - Dewey, Blake

AU - Freeman, Leorah

AU - Gauthier, Susan

AU - Henry, Roland

AU - Inglese, Mathilde

AU - Kolind, Shannon

AU - Li, David K.B.

AU - Mainero, Caterina

AU - Menon, Ravi S.

AU - Nair, Govind

AU - Narayanan, Sridar

AU - Nelson, Flavia

AU - Pelletier, Daniel

AU - Rauscher, Alexander

AU - Rooney, William

AU - Sati, Pascal

AU - Schwartz, Daniel

AU - Shinohara, Russell T.

AU - Tagge, Ian

AU - Traboulsee, Anthony

AU - Wang, Yi

AU - Yoo, Youngjin

AU - Yousry, Tarek

AU - Zhang, Yunyan

AU - Sicotte, Nancy L.

AU - Reich, Daniel S.

PY - 2019/3/12

Y1 - 2019/3/12

N2 - To summarize current and emerging imaging techniques that can be used to assess neuroprotection and repair in multiple sclerosis (MS), and to provide a consensus opinion on the potential utility of each technique in clinical trial settings.MethodsClinicians and scientists with expertise in the use of MRI in MS convened in Toronto, Canada, in November 2016 at a North American Imaging in Multiple Sclerosis (NAIMS) Cooperative workshop meeting. The discussion was compiled into a manuscript and circulated to all NAIMS members in attendance. Edits and feedback were incorporated until all authors were in agreement.ResultsA wide spectrum of imaging techniques and analysis methods in the context of specific study designs were discussed, with a focus on the utility and limitations of applying each technique to assess neuroprotection and repair. Techniques were discussed under specific themes, and included conventional imaging, magnetization transfer ratio, diffusion tensor imaging, susceptibility-weighted imaging, imaging cortical lesions, magnetic resonance spectroscopy, PET, advanced diffusion imaging, sodium imaging, multimodal techniques, imaging of special regions, statistical considerations, and study design.ConclusionsImaging biomarkers of neuroprotection and repair are an unmet need in MS. There are a number of promising techniques with different strengths and limitations, and selection of a specific technique will depend on a number of factors, notably the question the trial seeks to answer. Ongoing collaborative efforts will enable further refinement and improved methods to image the effect of novel therapeutic agents that exert benefit in MS predominately through neuroprotective and reparative mechanisms.

AB - To summarize current and emerging imaging techniques that can be used to assess neuroprotection and repair in multiple sclerosis (MS), and to provide a consensus opinion on the potential utility of each technique in clinical trial settings.MethodsClinicians and scientists with expertise in the use of MRI in MS convened in Toronto, Canada, in November 2016 at a North American Imaging in Multiple Sclerosis (NAIMS) Cooperative workshop meeting. The discussion was compiled into a manuscript and circulated to all NAIMS members in attendance. Edits and feedback were incorporated until all authors were in agreement.ResultsA wide spectrum of imaging techniques and analysis methods in the context of specific study designs were discussed, with a focus on the utility and limitations of applying each technique to assess neuroprotection and repair. Techniques were discussed under specific themes, and included conventional imaging, magnetization transfer ratio, diffusion tensor imaging, susceptibility-weighted imaging, imaging cortical lesions, magnetic resonance spectroscopy, PET, advanced diffusion imaging, sodium imaging, multimodal techniques, imaging of special regions, statistical considerations, and study design.ConclusionsImaging biomarkers of neuroprotection and repair are an unmet need in MS. There are a number of promising techniques with different strengths and limitations, and selection of a specific technique will depend on a number of factors, notably the question the trial seeks to answer. Ongoing collaborative efforts will enable further refinement and improved methods to image the effect of novel therapeutic agents that exert benefit in MS predominately through neuroprotective and reparative mechanisms.

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