Imaging opiate receptors in the human brain with positron emission tomography. Potential applications for drug addiction research

B. Sadzot, H. S. Mayberg, J. J. Frost

Research output: Contribution to journalArticle

Abstract

Positron emission tomography (PET) has been used mostly for the study of brain blood flow and metabolism in normal controls and in a variety of neurological and psychiatric conditions. With the appropriate radiotracers, PET also allows non-invasive imaging and quantification of a growing list of neuroceptors. 11C-carfentanil and 11C-diprenorphine, 2 potent opiate ligands, have been used to label opiate receptors in vivo in man. Some advantages and limitations of this technique are discussed. PET is a unique tool that could help us understand, at the receptor level, some biochemical aspects of addiction to opiate drugs. Specific questions can be answered, but carefully designed protocols are required.

Original languageEnglish (US)
Pages (from-to)9-19
Number of pages11
JournalActa Psychiatrica Belgica
Volume90
Issue number1
StatePublished - 1990

ASJC Scopus subject areas

  • Psychiatry and Mental health

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