Imaging of pancreatic islet cells

Research output: Contribution to journalReview articlepeer-review

Abstract

At present, the onset and progress of diabetes, and the efficacy of potential treatments, can only be assessed through indirect means, i.e. blood glucose, insulin, or C-peptide measurements. The development of non-invasive and reliable methods for (1) quantification of pancreatic beta islet cell mass in vivo, (2) determining endogenous islet function and survival, and (3) visualizing the biodistribution, survival, and function of transplanted exogenous islets are critical to further advance both basic science research and islet cell therapy in diabetes. Islet cell imaging using magnetic resonance, bioluminescence, positron emission tomography, or single photon emission computed tomography may provide us with a direct means to interrogate islet cell distribution, survival, and function. Current state-of-the-art strategies for beta-cell imaging are discussed and reviewed here in context of their clinical relevance.

Original languageEnglish (US)
Pages (from-to)761-766
Number of pages6
JournalDiabetes/Metabolism Research and Reviews
Volume27
Issue number8
DOIs
StatePublished - Nov 2011

Keywords

  • Bioluminescent imaging
  • Diabetes
  • Islets
  • Magnetic resonance imaging
  • Positron emission tomography
  • Transplantation

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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