Imaging of nonprostate cancers using PSMA-targeted radiotracers: Rationale, current state of the field, and a call to arms

A. Salas Fragomeni Roberto, Tali Amir, Sara Sheikhbahaei, Susan Harvey, Mehrbod Som Som Javadi, Lilja Solnes, Ana Ponce Kiess, Mohamad E Allaf, Martin Gilbert Pomper, Michael Gorin, Steven Rowe

Research output: Contribution to journalArticle

Abstract

Prostate-specific membrane antigen (PSMA) is a type II transmem-brane glycoprotein that is highly overexpressed on prostate cancer epithelial cells and for which there is a growing body of literature examining the role of small-molecule and antibody radiotracers targeted against this protein for prostate cancer detection and therapy. Despite its name, PSMA is also expressed, to varying degrees, in the neovasculature of a wide variety of nonprostate cancers; indeed, the pathology literature is replete with promising immunohistochemistry findings. Several groups have begun to correlate those pathology-level results with in vivo imaging and therapy in nonprostate cancers using the same PSMA-targeted agents that have been so successful in prostate cancer. The potential to leverage radiotracers targeted to PSMA beyond prostate cancer is a promising approach for many cancers, and PSMA-targeted agents may be able to supplement or fill gaps left by other agents. However, to date, most of the reported findings with PSMA-targeted radiotracers in nonprostate malignancies have been in case reports and small case series, and the field must adopt a more thorough approach to the design and execution of larger prospective trials to realize the potential of these promising agents outside prostate cancer.

Original languageEnglish (US)
Pages (from-to)871-877
Number of pages7
JournalJournal of Nuclear Medicine
Volume59
Issue number6
DOIs
StatePublished - Jun 1 2018

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Keywords

  • Breast cancer
  • Lung cancer
  • PET
  • PSMA
  • Renal cell carcinoma

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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