Imaging of musculoskeletal bacterial infections by [124I]FIAU-PET/CT

Luis A. Diaz, Catherine A. Foss, Katherine Thornton, Sridhar Nimmagadda, Christopher J. Endres, Ovsev Uzuner, Thorsten M. Seyler, Slif D. Ulrich, Janet Conway, Chetan Bettegowda, Nishant Agrawal, Ian Cheong, Xiaosong Zhang, Paul W. Ladenson, Barry N. Vogelstein, Michael A. Mont, Shibin Zhou, Kenneth W. Kinzler, Bert Vogelstein, Martin G. Pomper

Research output: Contribution to journalArticlepeer-review

Abstract

Background. Traditional imaging techniques for the localization and monitoring of bacterial infections, although reasonably sensitive, suffer from a lack of specificity. This is particularly true for musculoskeletal infections. Bacteria possess a thymidine kinase (TK) whose substrate specificity is distinct from that of the major human TK. The substrate specificity difference has been exploited to develop a new imaging technique that can detect the presence of viable bacteria. Methodology/Principal Findings. Eight subjects with suspected musculoskeletal infections and one healthy control were studied by a combination of [124I]FIAU-positron emission tomography and CT ([124I]FIAU-PET/CT). All patients with proven musculoskeletal infections demonstrated positive [124I]FIAU-PET/CT signals in the sites of concern at two hours after radiopharmaceutical administration. No adverse reactions with FIAU were observed. Conclusions/Significance. [124I]FIAU-PET/CT is a promising new method for imaging bacterial infections.

Original languageEnglish (US)
Article numbere1007
JournalPloS one
Volume2
Issue number10
DOIs
StatePublished - Oct 10 2007

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

Fingerprint Dive into the research topics of 'Imaging of musculoskeletal bacterial infections by [<sup>124</sup>I]FIAU-PET/CT'. Together they form a unique fingerprint.

Cite this