Imaging of musculoskeletal bacterial infections by [124I]FIAU-PET/CT

Luis A. Diaz; Catherine A. Foss; Katherine Thornton; Sridhar Nimmagadda; Christopher J. Endres; Ovsev Uzuner; Thorsten M. Seyler; Slif D. Ulrich; Janet Conway; Chetan Bettegowda; Nishant Agrawal; Ian Cheong; Xiaosong Zhang; Paul W. Ladenson; Barry N. Vogelstein; Michael A. Mont; Shibin Zhou; Kenneth W. Kinzler; Bert Vogelstein; Martin G. Pomper

doi:10.1371/journal.pone.0001007

Imaging of musculoskeletal bacterial infections by [¹²⁴I]FIAU-PET/CT

Luis A. Diaz, Catherine A. Foss, Katherine Thornton, Sridhar Nimmagadda, Christopher J. Endres, Ovsev Uzuner, Thorsten M. Seyler, Slif D. Ulrich, Janet Conway, Chetan Bettegowda, Nishant Agrawal, Ian Cheong, Xiaosong Zhang, Paul W. Ladenson, Barry N. Vogelstein, Michael A. Mont, Shibin Zhou, Kenneth W. Kinzler, Bert Vogelstein, Martin G. Pomper

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Abstract

Background. Traditional imaging techniques for the localization and monitoring of bacterial infections, although reasonably sensitive, suffer from a lack of specificity. This is particularly true for musculoskeletal infections. Bacteria possess a thymidine kinase (TK) whose substrate specificity is distinct from that of the major human TK. The substrate specificity difference has been exploited to develop a new imaging technique that can detect the presence of viable bacteria. Methodology/Principal Findings. Eight subjects with suspected musculoskeletal infections and one healthy control were studied by a combination of [¹²⁴I]FIAU-positron emission tomography and CT ([¹²⁴I]FIAU-PET/CT). All patients with proven musculoskeletal infections demonstrated positive [¹²⁴I]FIAU-PET/CT signals in the sites of concern at two hours after radiopharmaceutical administration. No adverse reactions with FIAU were observed. Conclusions/Significance. [¹²⁴I]FIAU-PET/CT is a promising new method for imaging bacterial infections.

Original language	English (US)
Article number	e1007
Journal	PloS one
Volume	2
Issue number	10
DOIs	https://doi.org/10.1371/journal.pone.0001007
State	Published - Oct 10 2007

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Diaz, L. A., Foss, C. A., Thornton, K., Nimmagadda, S., Endres, C. J., Uzuner, O., Seyler, T. M., Ulrich, S. D., Conway, J., Bettegowda, C., Agrawal, N., Cheong, I., Zhang, X., Ladenson, P. W., Vogelstein, B. N., Mont, M. A., Zhou, S., Kinzler, K. W., Vogelstein, B., & Pomper, M. G. (2007). Imaging of musculoskeletal bacterial infections by [¹²⁴I]FIAU-PET/CT. PloS one, 2(10), Article e1007. https://doi.org/10.1371/journal.pone.0001007

Diaz, LA, Foss, CA, Thornton, K, Nimmagadda, S, Endres, CJ, Uzuner, O, Seyler, TM, Ulrich, SD, Conway, J, Bettegowda, C, Agrawal, N, Cheong, I, Zhang, X, Ladenson, PW, Vogelstein, BN, Mont, MA, Zhou, S , Kinzler, KW , Vogelstein, B & Pomper, MG 2007, 'Imaging of musculoskeletal bacterial infections by [¹²⁴I]FIAU-PET/CT', PloS one, vol. 2, no. 10, e1007. https://doi.org/10.1371/journal.pone.0001007

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title = "Imaging of musculoskeletal bacterial infections by [124I]FIAU-PET/CT",

abstract = "Background. Traditional imaging techniques for the localization and monitoring of bacterial infections, although reasonably sensitive, suffer from a lack of specificity. This is particularly true for musculoskeletal infections. Bacteria possess a thymidine kinase (TK) whose substrate specificity is distinct from that of the major human TK. The substrate specificity difference has been exploited to develop a new imaging technique that can detect the presence of viable bacteria. Methodology/Principal Findings. Eight subjects with suspected musculoskeletal infections and one healthy control were studied by a combination of [124I]FIAU-positron emission tomography and CT ([124I]FIAU-PET/CT). All patients with proven musculoskeletal infections demonstrated positive [124I]FIAU-PET/CT signals in the sites of concern at two hours after radiopharmaceutical administration. No adverse reactions with FIAU were observed. Conclusions/Significance. [124I]FIAU-PET/CT is a promising new method for imaging bacterial infections.",

author = "Diaz, {Luis A.} and Foss, {Catherine A.} and Katherine Thornton and Sridhar Nimmagadda and Endres, {Christopher J.} and Ovsev Uzuner and Seyler, {Thorsten M.} and Ulrich, {Slif D.} and Janet Conway and Chetan Bettegowda and Nishant Agrawal and Ian Cheong and Xiaosong Zhang and Ladenson, {Paul W.} and Vogelstein, {Barry N.} and Mont, {Michael A.} and Shibin Zhou and Kinzler, {Kenneth W.} and Bert Vogelstein and Pomper, {Martin G.}",

year = "2007",

month = oct,

day = "10",

doi = "10.1371/journal.pone.0001007",

language = "English (US)",

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T1 - Imaging of musculoskeletal bacterial infections by [124I]FIAU-PET/CT

AU - Diaz, Luis A.

AU - Foss, Catherine A.

AU - Thornton, Katherine

AU - Nimmagadda, Sridhar

AU - Endres, Christopher J.

AU - Uzuner, Ovsev

AU - Seyler, Thorsten M.

AU - Ulrich, Slif D.

AU - Conway, Janet

AU - Bettegowda, Chetan

AU - Agrawal, Nishant

AU - Cheong, Ian

AU - Zhang, Xiaosong

AU - Ladenson, Paul W.

AU - Vogelstein, Barry N.

AU - Mont, Michael A.

AU - Zhou, Shibin

AU - Kinzler, Kenneth W.

AU - Vogelstein, Bert

AU - Pomper, Martin G.

PY - 2007/10/10

Y1 - 2007/10/10

N2 - Background. Traditional imaging techniques for the localization and monitoring of bacterial infections, although reasonably sensitive, suffer from a lack of specificity. This is particularly true for musculoskeletal infections. Bacteria possess a thymidine kinase (TK) whose substrate specificity is distinct from that of the major human TK. The substrate specificity difference has been exploited to develop a new imaging technique that can detect the presence of viable bacteria. Methodology/Principal Findings. Eight subjects with suspected musculoskeletal infections and one healthy control were studied by a combination of [124I]FIAU-positron emission tomography and CT ([124I]FIAU-PET/CT). All patients with proven musculoskeletal infections demonstrated positive [124I]FIAU-PET/CT signals in the sites of concern at two hours after radiopharmaceutical administration. No adverse reactions with FIAU were observed. Conclusions/Significance. [124I]FIAU-PET/CT is a promising new method for imaging bacterial infections.

AB - Background. Traditional imaging techniques for the localization and monitoring of bacterial infections, although reasonably sensitive, suffer from a lack of specificity. This is particularly true for musculoskeletal infections. Bacteria possess a thymidine kinase (TK) whose substrate specificity is distinct from that of the major human TK. The substrate specificity difference has been exploited to develop a new imaging technique that can detect the presence of viable bacteria. Methodology/Principal Findings. Eight subjects with suspected musculoskeletal infections and one healthy control were studied by a combination of [124I]FIAU-positron emission tomography and CT ([124I]FIAU-PET/CT). All patients with proven musculoskeletal infections demonstrated positive [124I]FIAU-PET/CT signals in the sites of concern at two hours after radiopharmaceutical administration. No adverse reactions with FIAU were observed. Conclusions/Significance. [124I]FIAU-PET/CT is a promising new method for imaging bacterial infections.

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Imaging of musculoskeletal bacterial infections by [¹²⁴I]FIAU-PET/CT

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