Imaging of lymphoma with PET with 2-[F-18]-fluoro-2-deoxy-D-glucose: correlation with CT

Joel S. Newman, Isaac R. Francis, Mark S. Kaminski, Richard L. Wahl

Research output: Contribution to journalArticle

Abstract

PURPOSE: To prospectively compare the accuracy of positron emission tomography (PET) with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG) in imaging thoracicoabdominal lymphoma to that of computed tomography (CT). MATERIALS AND METHODS: Sixteen patients with lymphoma (11 with non-Hodgkin lymphoma [NHL] and five with Hodgkin disease) underwent FDG-PET and CT. Blinded, independent interpretations of PET and CT studies were followed by a direct comparison of the images. Measurement of tumor uptake of FDG was performed on positive PET studies. RESULTS: Fifty-four foci of abnormal uptake were detected with PET in 13 patients. Forty-nine corresponding sites of lymphadenopathy and/or masses were detected with CT. All sites of adenopathy seen at CT were detected at PET. Three patients with Hodgkin disease had negative findings at abdominal PET, CT, and subsequent staging laparotomy. FDG uptake was comparable for both the low-and intermediate-grade lymphomas. CONCLUSION: These preliminary data indicate excellent accuracy for FDG-PET imaging of thoracicoabdominal lymphoma. All grades of NHL were successfully imaged with FDG-PET. PET appears to be a useful method for imaging lymphoma.

Original languageEnglish (US)
Pages (from-to)111-116
Number of pages6
JournalRadiology
Volume190
Issue number1
StatePublished - Jan 1994
Externally publishedYes

Fingerprint

Deoxyglucose
Positron-Emission Tomography
Lymphoma
Tomography
Non-Hodgkin's Lymphoma
Hodgkin Disease
Fluorine
Laparotomy
Positron Emission Tomography Computed Tomography
Neoplasms

Keywords

  • Computed tomography (CT), comparative studies, 60.12112
  • Emission CT, 60.12163
  • Emission CT, comparative studies 60.12163
  • Hodgkin disease, 60.342
  • Lymphoma, 60.342, 60.343
  • Lymphoma, CT, 60.12112

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Newman, J. S., Francis, I. R., Kaminski, M. S., & Wahl, R. L. (1994). Imaging of lymphoma with PET with 2-[F-18]-fluoro-2-deoxy-D-glucose: correlation with CT. Radiology, 190(1), 111-116.

Imaging of lymphoma with PET with 2-[F-18]-fluoro-2-deoxy-D-glucose : correlation with CT. / Newman, Joel S.; Francis, Isaac R.; Kaminski, Mark S.; Wahl, Richard L.

In: Radiology, Vol. 190, No. 1, 01.1994, p. 111-116.

Research output: Contribution to journalArticle

Newman, JS, Francis, IR, Kaminski, MS & Wahl, RL 1994, 'Imaging of lymphoma with PET with 2-[F-18]-fluoro-2-deoxy-D-glucose: correlation with CT', Radiology, vol. 190, no. 1, pp. 111-116.
Newman JS, Francis IR, Kaminski MS, Wahl RL. Imaging of lymphoma with PET with 2-[F-18]-fluoro-2-deoxy-D-glucose: correlation with CT. Radiology. 1994 Jan;190(1):111-116.
Newman, Joel S. ; Francis, Isaac R. ; Kaminski, Mark S. ; Wahl, Richard L. / Imaging of lymphoma with PET with 2-[F-18]-fluoro-2-deoxy-D-glucose : correlation with CT. In: Radiology. 1994 ; Vol. 190, No. 1. pp. 111-116.
@article{b9c6c5c1d02b478ba70b95b46be64c56,
title = "Imaging of lymphoma with PET with 2-[F-18]-fluoro-2-deoxy-D-glucose: correlation with CT",
abstract = "PURPOSE: To prospectively compare the accuracy of positron emission tomography (PET) with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG) in imaging thoracicoabdominal lymphoma to that of computed tomography (CT). MATERIALS AND METHODS: Sixteen patients with lymphoma (11 with non-Hodgkin lymphoma [NHL] and five with Hodgkin disease) underwent FDG-PET and CT. Blinded, independent interpretations of PET and CT studies were followed by a direct comparison of the images. Measurement of tumor uptake of FDG was performed on positive PET studies. RESULTS: Fifty-four foci of abnormal uptake were detected with PET in 13 patients. Forty-nine corresponding sites of lymphadenopathy and/or masses were detected with CT. All sites of adenopathy seen at CT were detected at PET. Three patients with Hodgkin disease had negative findings at abdominal PET, CT, and subsequent staging laparotomy. FDG uptake was comparable for both the low-and intermediate-grade lymphomas. CONCLUSION: These preliminary data indicate excellent accuracy for FDG-PET imaging of thoracicoabdominal lymphoma. All grades of NHL were successfully imaged with FDG-PET. PET appears to be a useful method for imaging lymphoma.",
keywords = "Computed tomography (CT), comparative studies, 60.12112, Emission CT, 60.12163, Emission CT, comparative studies 60.12163, Hodgkin disease, 60.342, Lymphoma, 60.342, 60.343, Lymphoma, CT, 60.12112",
author = "Newman, {Joel S.} and Francis, {Isaac R.} and Kaminski, {Mark S.} and Wahl, {Richard L.}",
year = "1994",
month = "1",
language = "English (US)",
volume = "190",
pages = "111--116",
journal = "Radiology",
issn = "0033-8419",
publisher = "Radiological Society of North America Inc.",
number = "1",

}

TY - JOUR

T1 - Imaging of lymphoma with PET with 2-[F-18]-fluoro-2-deoxy-D-glucose

T2 - correlation with CT

AU - Newman, Joel S.

AU - Francis, Isaac R.

AU - Kaminski, Mark S.

AU - Wahl, Richard L.

PY - 1994/1

Y1 - 1994/1

N2 - PURPOSE: To prospectively compare the accuracy of positron emission tomography (PET) with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG) in imaging thoracicoabdominal lymphoma to that of computed tomography (CT). MATERIALS AND METHODS: Sixteen patients with lymphoma (11 with non-Hodgkin lymphoma [NHL] and five with Hodgkin disease) underwent FDG-PET and CT. Blinded, independent interpretations of PET and CT studies were followed by a direct comparison of the images. Measurement of tumor uptake of FDG was performed on positive PET studies. RESULTS: Fifty-four foci of abnormal uptake were detected with PET in 13 patients. Forty-nine corresponding sites of lymphadenopathy and/or masses were detected with CT. All sites of adenopathy seen at CT were detected at PET. Three patients with Hodgkin disease had negative findings at abdominal PET, CT, and subsequent staging laparotomy. FDG uptake was comparable for both the low-and intermediate-grade lymphomas. CONCLUSION: These preliminary data indicate excellent accuracy for FDG-PET imaging of thoracicoabdominal lymphoma. All grades of NHL were successfully imaged with FDG-PET. PET appears to be a useful method for imaging lymphoma.

AB - PURPOSE: To prospectively compare the accuracy of positron emission tomography (PET) with 2-[fluorine-18]-fluoro-2-deoxy-D-glucose (FDG) in imaging thoracicoabdominal lymphoma to that of computed tomography (CT). MATERIALS AND METHODS: Sixteen patients with lymphoma (11 with non-Hodgkin lymphoma [NHL] and five with Hodgkin disease) underwent FDG-PET and CT. Blinded, independent interpretations of PET and CT studies were followed by a direct comparison of the images. Measurement of tumor uptake of FDG was performed on positive PET studies. RESULTS: Fifty-four foci of abnormal uptake were detected with PET in 13 patients. Forty-nine corresponding sites of lymphadenopathy and/or masses were detected with CT. All sites of adenopathy seen at CT were detected at PET. Three patients with Hodgkin disease had negative findings at abdominal PET, CT, and subsequent staging laparotomy. FDG uptake was comparable for both the low-and intermediate-grade lymphomas. CONCLUSION: These preliminary data indicate excellent accuracy for FDG-PET imaging of thoracicoabdominal lymphoma. All grades of NHL were successfully imaged with FDG-PET. PET appears to be a useful method for imaging lymphoma.

KW - Computed tomography (CT), comparative studies, 60.12112

KW - Emission CT, 60.12163

KW - Emission CT, comparative studies 60.12163

KW - Hodgkin disease, 60.342

KW - Lymphoma, 60.342, 60.343

KW - Lymphoma, CT, 60.12112

UR - http://www.scopus.com/inward/record.url?scp=0027976730&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027976730&partnerID=8YFLogxK

M3 - Article

C2 - 8259386

AN - SCOPUS:0027976730

VL - 190

SP - 111

EP - 116

JO - Radiology

JF - Radiology

SN - 0033-8419

IS - 1

ER -