Imaging metabolic and molecular functions in brain tumors with positron emission tomography (PET)

Beril Gok, Richard L. Wahl

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Molecular imaging is the amalgamation of molecular biology and imaging technology in a unique way that enables in vivo observation of molecular biological processes without altering the process or organism being studied. Positron Emission Tomography (PET) is the most advanced form of molecular imaging suitable for broad application in human. Since positron-emitting radionuclides of elements such as C, N, O, and F can replace the stable analogues in drugs and biomolecules of fundamental biochemical principles, it is possible to synthesize PET probes with the same chemical structure as the parent unlabeled molecules without altering their biological activity. Fundamental biochemical principles comprise several potential targets including the receptors on the tumor surface, targeting agents based on increased metabolic demands of the cancer, and potentially enzymes or processes which are related to cell growth and survival. Characteristics of the microenvironment of tumors, including tumor perfusion and hypoxia, can also be targeted as well as elements of the tumor stroma. In brain tumors, molecular imaging with PET might allow (1) Differential diagnosis and grading, (2) Determination of prognosis, (3) Determination of the exact localization, extent, and metabolic activity of biologically active brain tumors for establishing the target for therapy, (4) Evaluation of the response to treatment, (5) Differentiation between treatment induced lesions and residual or recurrent tumor tissue, (6) Evaluation of function changes within the surrounding brain tissue which need to be assessed for the determination of the pharmacodynamic and neurotoxicity of therapeutic agents. Along with the advances in molecular biology, the effectiveness of PET with noninvasive biomarkers will become increasingly important.

Original languageEnglish (US)
Title of host publicationFunctional Brain Tumor Imaging
PublisherSpringer New York
Pages129-142
Number of pages14
ISBN (Print)9781441958587, 1441958576, 9781441958570
DOIs
StatePublished - May 1 2013

Fingerprint

Positron emission tomography
Molecular Imaging
Brain Neoplasms
Positron-Emission Tomography
Tumors
Brain
Molecular imaging
Imaging techniques
Molecular Biology
Neoplasms
Molecular biology
Biological Phenomena
Tumor Microenvironment
Radioisotopes
Cell Survival
Pharmacodynamics
Differential Diagnosis
Tissue
Perfusion
Biomarkers

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Gok, B., & Wahl, R. L. (2013). Imaging metabolic and molecular functions in brain tumors with positron emission tomography (PET). In Functional Brain Tumor Imaging (pp. 129-142). Springer New York. https://doi.org/10.1007/978-1-4419-5858-7_8

Imaging metabolic and molecular functions in brain tumors with positron emission tomography (PET). / Gok, Beril; Wahl, Richard L.

Functional Brain Tumor Imaging. Springer New York, 2013. p. 129-142.

Research output: Chapter in Book/Report/Conference proceedingChapter

Gok, Beril ; Wahl, Richard L. / Imaging metabolic and molecular functions in brain tumors with positron emission tomography (PET). Functional Brain Tumor Imaging. Springer New York, 2013. pp. 129-142
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