TY - JOUR
T1 - Imaging genetics of brain longevity and mental wellness
T2 - The next frontier?
AU - Petrella, Jeffrey R.
AU - Mattay, Venkata S.
AU - Doraiswamy, P. Murali
PY - 2008/1
Y1 - 2008/1
N2 - The advent of new "omics" technologies (genomics, proteomics, and metabolomics) has ushered in a new era of biomedical discovery that is already affecting every field of medicine. With the rapid growth of the older population worldwide, there is great interest in applying these technologies not only to diagnose and prevent disease, but also to enhance brain longevity and mental wellness. Nearly two-thirds of the approximately 30 000 genes in the human genome are related to brain function, and up to half of the variance in age-related changes in cognition, brain volume, and neuronal function appears to be genetically determined. Selected examples will be used to illustrate how neuroimaging is being employed to study the effects of genes and how neurogenetics may affect future radiology research and practice.
AB - The advent of new "omics" technologies (genomics, proteomics, and metabolomics) has ushered in a new era of biomedical discovery that is already affecting every field of medicine. With the rapid growth of the older population worldwide, there is great interest in applying these technologies not only to diagnose and prevent disease, but also to enhance brain longevity and mental wellness. Nearly two-thirds of the approximately 30 000 genes in the human genome are related to brain function, and up to half of the variance in age-related changes in cognition, brain volume, and neuronal function appears to be genetically determined. Selected examples will be used to illustrate how neuroimaging is being employed to study the effects of genes and how neurogenetics may affect future radiology research and practice.
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U2 - 10.1148/radiol.2461061994
DO - 10.1148/radiol.2461061994
M3 - Review article
C2 - 18096526
AN - SCOPUS:37349066507
SN - 0033-8419
VL - 246
SP - 20
EP - 32
JO - RADIOLOGY
JF - RADIOLOGY
IS - 1
ER -