Imaging genetic influences in human brain function

Venkata S. Mattay, Terry E. Goldberg

Research output: Contribution to journalReview articlepeer-review

Abstract

The association between genes and brain function using functional brain imaging techniques is an emerging and promising area of research that will help to better characterize the influence of genes on cognition and behavior as well as the link between genetic susceptibility and neuropsychiatric disorders. Neurophysiological imaging provides information regarding the effect of genes on brain function at the level of information processing, and neurochemical imaging provides information on the intrinsic mechanisms on how these genes affect the brain response. In this review, we highlight recent studies that have begun to explore the influence of genetic mutations on brain function with these techniques. The results, even from these few studies, illustrate the potential of these techniques to provide a more sensitive assay than behavioral measures used alone. The results also show that neuroimaging techniques can elucidate the influence of genes on brain function in relatively small sample populations, sometimes even in the absence of significant differences in behavioral measures.

Original languageEnglish (US)
Pages (from-to)239-247
Number of pages9
JournalCurrent Opinion in Neurobiology
Volume14
Issue number2
DOIs
StatePublished - Apr 1 2004
Externally publishedYes

Keywords

  • 5-HT
  • 5-HTT
  • AD
  • APOE
  • Alzheimer's disease
  • Apolipoprotein E
  • BDNF
  • BOLD fMRI
  • Blood oxygenation level dependent functional magnetic resonance imaging
  • Brain derived neurotrophic factor
  • COMT
  • Catechol-O-methyl transferase
  • DA
  • Serotonin
  • Serotonin transporter

ASJC Scopus subject areas

  • Neuroscience(all)

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