TY - JOUR
T1 - Imaging findings of bisphosphonate-related osteonecrosis of the jaw with emphasis on early magnetic resonance imaging findings
AU - Krishnan, Anant
AU - Arslanoglu, Atilla
AU - Yildirm, Nadir
AU - Silbergleit, Richard
AU - Aygun, Nafi
PY - 2009
Y1 - 2009
N2 - PURPOSE: To describe the imaging findings of bisphosphonate-related osteonecrosis of the jaw (BRONJ) with emphasis on early magnetic resonance imaging (MRI) findings. MATERIALS AND METHODS: The medical records and computed tomography, MRI, and bone scintigraphy images of 5 female and 1male patients (n = 6) between the ages of 49 and 79 years (mean age, 70 years) who had a diagnosis of BRONJ were retrospectively reviewed, and temporal changes in imaging features were noted. RESULTS: The earliest MRI finding was the loss of the normal T1 hyperintensity of fatty marrow in the mandible and maxilla. The MRI findings of more advanced BRONJ included bone destruction, soft tissue edema and enhancement, inferior alveolar nerve thickening, and pterygoid muscle swelling and enhancement. On computed tomography, sclerosis and subtle lucencies (widening) of the periodontal ligament and cortex and around the apices of the teeth in the early stage, and osteolytic bone lesions, cortical disruption, and frank bone fragmentation in the later stages were observed. Bone scintigraphy showed increased uptake early in the disease. CONCLUSIONS: Osteonecrosis of the mandible and maxilla occurs as a complication of bisphosphonate treatment of bone metastasis and osteoporosis and typically manifests after a dental procedure. Magnetic resonance imaging and bone scintigraphy findings may precede clinical symptoms and mimic metastatic disease.
AB - PURPOSE: To describe the imaging findings of bisphosphonate-related osteonecrosis of the jaw (BRONJ) with emphasis on early magnetic resonance imaging (MRI) findings. MATERIALS AND METHODS: The medical records and computed tomography, MRI, and bone scintigraphy images of 5 female and 1male patients (n = 6) between the ages of 49 and 79 years (mean age, 70 years) who had a diagnosis of BRONJ were retrospectively reviewed, and temporal changes in imaging features were noted. RESULTS: The earliest MRI finding was the loss of the normal T1 hyperintensity of fatty marrow in the mandible and maxilla. The MRI findings of more advanced BRONJ included bone destruction, soft tissue edema and enhancement, inferior alveolar nerve thickening, and pterygoid muscle swelling and enhancement. On computed tomography, sclerosis and subtle lucencies (widening) of the periodontal ligament and cortex and around the apices of the teeth in the early stage, and osteolytic bone lesions, cortical disruption, and frank bone fragmentation in the later stages were observed. Bone scintigraphy showed increased uptake early in the disease. CONCLUSIONS: Osteonecrosis of the mandible and maxilla occurs as a complication of bisphosphonate treatment of bone metastasis and osteoporosis and typically manifests after a dental procedure. Magnetic resonance imaging and bone scintigraphy findings may precede clinical symptoms and mimic metastatic disease.
KW - Bisphosphonate
KW - CT
KW - Jaw
KW - MRI
KW - Mandible
KW - Osteonecrosis
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U2 - 10.1097/RCT.0b013e31817e4986
DO - 10.1097/RCT.0b013e31817e4986
M3 - Article
C2 - 19346864
AN - SCOPUS:64749113650
SN - 0363-8715
VL - 33
SP - 298
EP - 304
JO - Journal of computer assisted tomography
JF - Journal of computer assisted tomography
IS - 2
ER -