TY - JOUR
T1 - Imaging Features of Idiopathic Intracranial Hypertension in Children
AU - Hartmann, Alexander J.P.W.
AU - Soares, Bruno P.
AU - Bruce, Beau B.
AU - Saindane, Amit M.
AU - Newman, Nancy J.
AU - Biousse, Valérie
AU - Peragallo, Jason H.
N1 - Funding Information:
This study was supported by a grant from the Research to Prevent Blindness, and by the NIH/NEI core grant P30-EY06360 (Department of Ophthalmology, Emory University). BBB is a consultant for MedImmune (data and safety monitoring board) and Bayer (medicolegal). NJN is a consultant for GenSight Biologics, Trius Therapeutics, and Santhera. VB is a consultant for GenSight Biologics.
Publisher Copyright:
© SAGE Publications.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Magnetic resonance imaging (MRI) signs of elevated intracranial pressure and idiopathic intracranial hypertension have been well characterized in adults but not in children. The MRIs of 50 children with idiopathic intracranial hypertension and 46 adults with idiopathic intracranial hypertension were reviewed for optic nerve head protrusion, optic nerve head enhancement, posterior scleral flattening, increased perioptic cerebrospinal fluid, optic nerve tortuosity, empty or partially empty sella, tonsillar herniation, enlargement of Meckel's cave meningoceles, and transverse venous sinus stenosis(TSS). Compared to adolescents (11-17 years, n = 40) and adults (>17 years, n = 46), prepubescent children (<11 years, n = 10) had lower frequencies of scleral flattening (50% vs 89% and 85%, P =.02), increased perioptic cerebrospinal fluid (60% vs 84% and 89%, P =.08), optic nerve tortuosity (20% vs 46% and 59%, P =.07), empty or partially empty sella (56% vs 78% and 93%, P =.007), and TSS (67% vs 93% and 96%, P =.04). Children with idiopathic intracranial hypertension have similar MRI findings as adults, but they are less frequent in prepubescent children.
AB - Magnetic resonance imaging (MRI) signs of elevated intracranial pressure and idiopathic intracranial hypertension have been well characterized in adults but not in children. The MRIs of 50 children with idiopathic intracranial hypertension and 46 adults with idiopathic intracranial hypertension were reviewed for optic nerve head protrusion, optic nerve head enhancement, posterior scleral flattening, increased perioptic cerebrospinal fluid, optic nerve tortuosity, empty or partially empty sella, tonsillar herniation, enlargement of Meckel's cave meningoceles, and transverse venous sinus stenosis(TSS). Compared to adolescents (11-17 years, n = 40) and adults (>17 years, n = 46), prepubescent children (<11 years, n = 10) had lower frequencies of scleral flattening (50% vs 89% and 85%, P =.02), increased perioptic cerebrospinal fluid (60% vs 84% and 89%, P =.08), optic nerve tortuosity (20% vs 46% and 59%, P =.07), empty or partially empty sella (56% vs 78% and 93%, P =.007), and TSS (67% vs 93% and 96%, P =.04). Children with idiopathic intracranial hypertension have similar MRI findings as adults, but they are less frequent in prepubescent children.
KW - MRI
KW - Pseudotumor cerebri
KW - intracranial pressure
KW - pediatric
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U2 - 10.1177/0883073816671855
DO - 10.1177/0883073816671855
M3 - Article
C2 - 28195748
AN - SCOPUS:85006499517
VL - 32
SP - 120
EP - 126
JO - Journal of Child Neurology
JF - Journal of Child Neurology
SN - 0883-0738
IS - 1
ER -