Imaging cortical association tracts in the human brain using diffusion-tensor-based axonal tracking

Susumu Mori, Walter E. Kaufmann, Christos Davatzikos, Bram Stieltjes, Laura Amodei, Kim Fredericksen, Godfrey D. Pearlson, Elias R. Melhem, Meiyappan Solaiyappan, Gerald V. Raymond, Hugo W. Moser, Peter C.M. Van Zijl

Research output: Contribution to journalArticle

Abstract

Diffusion-tensor fiber tracking was used to identify the cores of several long-association fibers, including the anterior (ATR) and posterior (PTR) thalamic radiations, and the uncinate (UNC), superior longitudinal (SLF), inferior longitudinal (ILF), and inferior fronto-occipital (IFO) fasciculi. Tracking results were compared to existing anatomical knowledge, and showed good qualitative agreement. Guidelines were developed to reproducibly track these fibers in vivo. The interindividual variability of these reconstructions was assessed in a common spatial reference frame (Talairach space) using probabilistic mapping. As a first illustration of this technical capability, a reduction in brain connectivity in a patient with a childhood neurodegenerative disease (X-linked adrenoleukodystrophy) was demonstrated.

Original languageEnglish (US)
Pages (from-to)215-223
Number of pages9
JournalMagnetic resonance in medicine
Volume47
Issue number2
DOIs
StatePublished - Feb 12 2002

Keywords

  • Association
  • Axonal
  • Diffusion
  • MRI
  • Tensor
  • Tracts

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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    Mori, S., Kaufmann, W. E., Davatzikos, C., Stieltjes, B., Amodei, L., Fredericksen, K., Pearlson, G. D., Melhem, E. R., Solaiyappan, M., Raymond, G. V., Moser, H. W., & Van Zijl, P. C. M. (2002). Imaging cortical association tracts in the human brain using diffusion-tensor-based axonal tracking. Magnetic resonance in medicine, 47(2), 215-223. https://doi.org/10.1002/mrm.10074