Imaging cortical association tracts in the human brain using diffusion-tensor-based axonal tracking

Susumu Mori, Walter E. Kaufmann, Christos Davatzikos, Bram Stieltjes, Laura Amodei, Kim Fredericksen, Godfrey D. Pearlson, Elias R. Melhem, Meiyappan Solaiyappan, Gerald V. Raymond, Hugo W. Moser, Peter C Van Zijl

Research output: Contribution to journalArticle

Abstract

Diffusion-tensor fiber tracking was used to identify the cores of several long-association fibers, including the anterior (ATR) and posterior (PTR) thalamic radiations, and the uncinate (UNC), superior longitudinal (SLF), inferior longitudinal (ILF), and inferior fronto-occipital (IFO) fasciculi. Tracking results were compared to existing anatomical knowledge, and showed good qualitative agreement. Guidelines were developed to reproducibly track these fibers in vivo. The interindividual variability of these reconstructions was assessed in a common spatial reference frame (Talairach space) using probabilistic mapping. As a first illustration of this technical capability, a reduction in brain connectivity in a patient with a childhood neurodegenerative disease (X-linked adrenoleukodystrophy) was demonstrated.

Original languageEnglish (US)
Pages (from-to)215-223
Number of pages9
JournalMagnetic Resonance in Medicine
Volume47
Issue number2
DOIs
StatePublished - 2002

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Adrenoleukodystrophy
Neurodegenerative Diseases
Guidelines
Radiation
Brain

Keywords

  • Association
  • Axonal
  • Diffusion
  • MRI
  • Tensor
  • Tracts

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Imaging cortical association tracts in the human brain using diffusion-tensor-based axonal tracking. / Mori, Susumu; Kaufmann, Walter E.; Davatzikos, Christos; Stieltjes, Bram; Amodei, Laura; Fredericksen, Kim; Pearlson, Godfrey D.; Melhem, Elias R.; Solaiyappan, Meiyappan; Raymond, Gerald V.; Moser, Hugo W.; Van Zijl, Peter C.

In: Magnetic Resonance in Medicine, Vol. 47, No. 2, 2002, p. 215-223.

Research output: Contribution to journalArticle

Mori, S, Kaufmann, WE, Davatzikos, C, Stieltjes, B, Amodei, L, Fredericksen, K, Pearlson, GD, Melhem, ER, Solaiyappan, M, Raymond, GV, Moser, HW & Van Zijl, PC 2002, 'Imaging cortical association tracts in the human brain using diffusion-tensor-based axonal tracking', Magnetic Resonance in Medicine, vol. 47, no. 2, pp. 215-223. https://doi.org/10.1002/mrm.10074
Mori, Susumu ; Kaufmann, Walter E. ; Davatzikos, Christos ; Stieltjes, Bram ; Amodei, Laura ; Fredericksen, Kim ; Pearlson, Godfrey D. ; Melhem, Elias R. ; Solaiyappan, Meiyappan ; Raymond, Gerald V. ; Moser, Hugo W. ; Van Zijl, Peter C. / Imaging cortical association tracts in the human brain using diffusion-tensor-based axonal tracking. In: Magnetic Resonance in Medicine. 2002 ; Vol. 47, No. 2. pp. 215-223.
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AU - Mori, Susumu

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AU - Amodei, Laura

AU - Fredericksen, Kim

AU - Pearlson, Godfrey D.

AU - Melhem, Elias R.

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AB - Diffusion-tensor fiber tracking was used to identify the cores of several long-association fibers, including the anterior (ATR) and posterior (PTR) thalamic radiations, and the uncinate (UNC), superior longitudinal (SLF), inferior longitudinal (ILF), and inferior fronto-occipital (IFO) fasciculi. Tracking results were compared to existing anatomical knowledge, and showed good qualitative agreement. Guidelines were developed to reproducibly track these fibers in vivo. The interindividual variability of these reconstructions was assessed in a common spatial reference frame (Talairach space) using probabilistic mapping. As a first illustration of this technical capability, a reduction in brain connectivity in a patient with a childhood neurodegenerative disease (X-linked adrenoleukodystrophy) was demonstrated.

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