TY - JOUR
T1 - Imaging changes following stereotactic radiosurgery for metastatic intracranial tumors
T2 - Differentiating pseudoprogression from tumor progression and its effect on clinical practice
AU - Ruzevick, Jacob
AU - Kleinberg, Lawrence
AU - Rigamonti, Daniele
PY - 2014/4
Y1 - 2014/4
N2 - Stereotactic radiosurgery has become standard adjuvant treatment for patients with metastatic intracranial lesions. There has been a growing appreciation for benign imaging changes following radiation that are difficult to distinguish from true tumor progression. These imaging changes, termed pseudoprogression, carry significant implications for patient management. In this review, we discuss the current understanding of pseudoprogression in metastatic brain lesions, research to differentiate pseudoprogression from true progression, and clinical implications of pseudoprogression on treatment decisions.
AB - Stereotactic radiosurgery has become standard adjuvant treatment for patients with metastatic intracranial lesions. There has been a growing appreciation for benign imaging changes following radiation that are difficult to distinguish from true tumor progression. These imaging changes, termed pseudoprogression, carry significant implications for patient management. In this review, we discuss the current understanding of pseudoprogression in metastatic brain lesions, research to differentiate pseudoprogression from true progression, and clinical implications of pseudoprogression on treatment decisions.
KW - Brain metastases
KW - Pseudoprogression
KW - Stereotactic radiosurgery
UR - http://www.scopus.com/inward/record.url?scp=84897104049&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84897104049&partnerID=8YFLogxK
U2 - 10.1007/s10143-013-0504-8
DO - 10.1007/s10143-013-0504-8
M3 - Review article
C2 - 24233257
AN - SCOPUS:84897104049
VL - 37
SP - 193
EP - 201
JO - Neurosurgical Review
JF - Neurosurgical Review
SN - 0344-5607
IS - 2
ER -