Imaging changes following stereotactic radiosurgery for metastatic intracranial tumors: Differentiating pseudoprogression from tumor progression and its effect on clinical practice

Jacob Ruzevick, Lawrence Kleinberg, Daniele Rigamonti

Research output: Contribution to journalReview articlepeer-review

Abstract

Stereotactic radiosurgery has become standard adjuvant treatment for patients with metastatic intracranial lesions. There has been a growing appreciation for benign imaging changes following radiation that are difficult to distinguish from true tumor progression. These imaging changes, termed pseudoprogression, carry significant implications for patient management. In this review, we discuss the current understanding of pseudoprogression in metastatic brain lesions, research to differentiate pseudoprogression from true progression, and clinical implications of pseudoprogression on treatment decisions.

Original languageEnglish (US)
Pages (from-to)193-201
Number of pages9
JournalNeurosurgical Review
Volume37
Issue number2
DOIs
StatePublished - Apr 2014

Keywords

  • Brain metastases
  • Pseudoprogression
  • Stereotactic radiosurgery

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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