Imaging biomarker roadmap for cancer studies

James P B O'Connor, Eric O. Aboagye, Judith E. Adams, Hugo J W L Aerts, Sally F. Barrington, Ambros J. Beer, Ronald Boellaard, Sarah E. Bohndiek, Michael Brady, Gina Brown, David L. Buckley, Thomas L. Chenevert, Laurence P. Clarke, Sandra Collette, Gary J. Cook, Nandita M. deSouza, John C. Dickson, Caroline Dive, Jeffrey L. Evelhoch, Corinne Faivre-FinnFerdia A. Gallagher, Fiona J. Gilbert, Robert J. Gillies, Vicky Goh, John R. Griffiths, Ashley M. Groves, Steve Halligan, Adrian L. Harris, David J. Hawkes, Otto S. Hoekstra, Erich P. Huang, Brian F. Hutton, Edward F. Jackson, Gordon C. Jayson, Andrew Jones, Dow Mu Koh, Denis Lacombe, Philippe Lambin, Nathalie Lassau, Martin O. Leach, Ting Yim Lee, Edward L. Leen, Jason S. Lewis, Yan Liu, Mark F. Lythgoe, Prakash Manoharan, Ross J. Maxwell, Kenneth A. Miles, Bruno Morgan, Steve Morris, Tony Ng, Anwar R. Padhani, Geoff J M Parker, Mike Partridge, Arvind Pathak, Andrew C. Peet, Shonit Punwani, Andrew R. Reynolds, Simon P. Robinson, Lalitha K. Shankar, Ricky A. Sharma, Dmitry Soloviev, Sigrid Stroobants, Daniel C. Sullivan, Stuart A. Taylor, Paul S. Tofts, Gillian M. Tozer, Marcel van Herk, Simon Walker-Samuel, James Wason, Kaye J. Williams, Paul Workman, Thomas E. Yankeelov, Kevin M. Brindle, Lisa M. McShane, Alan Jackson, John C. Waterton

Research output: Contribution to journalArticle

Abstract

Imaging biomarkers (IBs) are integral to the routine management of patients with cancer. IBs used daily in oncology include clinical TNM stage, objective response and left ventricular ejection fraction. Other CT, MRI, PET and ultrasonography biomarkers are used extensively in cancer research and drug development. New IBs need to be established either as useful tools for testing research hypotheses in clinical trials and research studies, or as clinical decision-making tools for use in healthcare, by crossing 'translational gaps' through validation and qualification. Important differences exist between IBs and biospecimen-derived biomarkers and, therefore, the development of IBs requires a tailored 'roadmap'. Recognizing this need, Cancer Research UK (CRUK) and the European Organisation for Research and Treatment of Cancer (EORTC) assembled experts to review, debate and summarize the challenges of IB validation and qualification. This consensus group has produced 14 key recommendations for accelerating the clinical translation of IBs, which highlight the role of parallel (rather than sequential) tracks of technical (assay) validation, biological/clinical validation and assessment of cost-effectiveness; the need for IB standardization and accreditation systems; the need to continually revisit IB precision; an alternative framework for biological/clinical validation of IBs; and the essential requirements for multicentre studies to qualify IBs for clinical use.

Original languageEnglish (US)
JournalNature Reviews Clinical Oncology
DOIs
StateAccepted/In press - Oct 11 2016

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Tumor Biomarkers
Biomarkers
Research
Neoplasms
Medical Oncology
Accreditation
Biological Assay
Stroke Volume
Multicenter Studies
Cost-Benefit Analysis
Ultrasonography
Clinical Trials

ASJC Scopus subject areas

  • Oncology

Cite this

O'Connor, J. P. B., Aboagye, E. O., Adams, J. E., Aerts, H. J. W. L., Barrington, S. F., Beer, A. J., ... Waterton, J. C. (Accepted/In press). Imaging biomarker roadmap for cancer studies. Nature Reviews Clinical Oncology. https://doi.org/10.1038/nrclinonc.2016.162

Imaging biomarker roadmap for cancer studies. / O'Connor, James P B; Aboagye, Eric O.; Adams, Judith E.; Aerts, Hugo J W L; Barrington, Sally F.; Beer, Ambros J.; Boellaard, Ronald; Bohndiek, Sarah E.; Brady, Michael; Brown, Gina; Buckley, David L.; Chenevert, Thomas L.; Clarke, Laurence P.; Collette, Sandra; Cook, Gary J.; deSouza, Nandita M.; Dickson, John C.; Dive, Caroline; Evelhoch, Jeffrey L.; Faivre-Finn, Corinne; Gallagher, Ferdia A.; Gilbert, Fiona J.; Gillies, Robert J.; Goh, Vicky; Griffiths, John R.; Groves, Ashley M.; Halligan, Steve; Harris, Adrian L.; Hawkes, David J.; Hoekstra, Otto S.; Huang, Erich P.; Hutton, Brian F.; Jackson, Edward F.; Jayson, Gordon C.; Jones, Andrew; Koh, Dow Mu; Lacombe, Denis; Lambin, Philippe; Lassau, Nathalie; Leach, Martin O.; Lee, Ting Yim; Leen, Edward L.; Lewis, Jason S.; Liu, Yan; Lythgoe, Mark F.; Manoharan, Prakash; Maxwell, Ross J.; Miles, Kenneth A.; Morgan, Bruno; Morris, Steve; Ng, Tony; Padhani, Anwar R.; Parker, Geoff J M; Partridge, Mike; Pathak, Arvind; Peet, Andrew C.; Punwani, Shonit; Reynolds, Andrew R.; Robinson, Simon P.; Shankar, Lalitha K.; Sharma, Ricky A.; Soloviev, Dmitry; Stroobants, Sigrid; Sullivan, Daniel C.; Taylor, Stuart A.; Tofts, Paul S.; Tozer, Gillian M.; van Herk, Marcel; Walker-Samuel, Simon; Wason, James; Williams, Kaye J.; Workman, Paul; Yankeelov, Thomas E.; Brindle, Kevin M.; McShane, Lisa M.; Jackson, Alan; Waterton, John C.

In: Nature Reviews Clinical Oncology, 11.10.2016.

Research output: Contribution to journalArticle

O'Connor, JPB, Aboagye, EO, Adams, JE, Aerts, HJWL, Barrington, SF, Beer, AJ, Boellaard, R, Bohndiek, SE, Brady, M, Brown, G, Buckley, DL, Chenevert, TL, Clarke, LP, Collette, S, Cook, GJ, deSouza, NM, Dickson, JC, Dive, C, Evelhoch, JL, Faivre-Finn, C, Gallagher, FA, Gilbert, FJ, Gillies, RJ, Goh, V, Griffiths, JR, Groves, AM, Halligan, S, Harris, AL, Hawkes, DJ, Hoekstra, OS, Huang, EP, Hutton, BF, Jackson, EF, Jayson, GC, Jones, A, Koh, DM, Lacombe, D, Lambin, P, Lassau, N, Leach, MO, Lee, TY, Leen, EL, Lewis, JS, Liu, Y, Lythgoe, MF, Manoharan, P, Maxwell, RJ, Miles, KA, Morgan, B, Morris, S, Ng, T, Padhani, AR, Parker, GJM, Partridge, M, Pathak, A, Peet, AC, Punwani, S, Reynolds, AR, Robinson, SP, Shankar, LK, Sharma, RA, Soloviev, D, Stroobants, S, Sullivan, DC, Taylor, SA, Tofts, PS, Tozer, GM, van Herk, M, Walker-Samuel, S, Wason, J, Williams, KJ, Workman, P, Yankeelov, TE, Brindle, KM, McShane, LM, Jackson, A & Waterton, JC 2016, 'Imaging biomarker roadmap for cancer studies', Nature Reviews Clinical Oncology. https://doi.org/10.1038/nrclinonc.2016.162
O'Connor JPB, Aboagye EO, Adams JE, Aerts HJWL, Barrington SF, Beer AJ et al. Imaging biomarker roadmap for cancer studies. Nature Reviews Clinical Oncology. 2016 Oct 11. https://doi.org/10.1038/nrclinonc.2016.162
O'Connor, James P B ; Aboagye, Eric O. ; Adams, Judith E. ; Aerts, Hugo J W L ; Barrington, Sally F. ; Beer, Ambros J. ; Boellaard, Ronald ; Bohndiek, Sarah E. ; Brady, Michael ; Brown, Gina ; Buckley, David L. ; Chenevert, Thomas L. ; Clarke, Laurence P. ; Collette, Sandra ; Cook, Gary J. ; deSouza, Nandita M. ; Dickson, John C. ; Dive, Caroline ; Evelhoch, Jeffrey L. ; Faivre-Finn, Corinne ; Gallagher, Ferdia A. ; Gilbert, Fiona J. ; Gillies, Robert J. ; Goh, Vicky ; Griffiths, John R. ; Groves, Ashley M. ; Halligan, Steve ; Harris, Adrian L. ; Hawkes, David J. ; Hoekstra, Otto S. ; Huang, Erich P. ; Hutton, Brian F. ; Jackson, Edward F. ; Jayson, Gordon C. ; Jones, Andrew ; Koh, Dow Mu ; Lacombe, Denis ; Lambin, Philippe ; Lassau, Nathalie ; Leach, Martin O. ; Lee, Ting Yim ; Leen, Edward L. ; Lewis, Jason S. ; Liu, Yan ; Lythgoe, Mark F. ; Manoharan, Prakash ; Maxwell, Ross J. ; Miles, Kenneth A. ; Morgan, Bruno ; Morris, Steve ; Ng, Tony ; Padhani, Anwar R. ; Parker, Geoff J M ; Partridge, Mike ; Pathak, Arvind ; Peet, Andrew C. ; Punwani, Shonit ; Reynolds, Andrew R. ; Robinson, Simon P. ; Shankar, Lalitha K. ; Sharma, Ricky A. ; Soloviev, Dmitry ; Stroobants, Sigrid ; Sullivan, Daniel C. ; Taylor, Stuart A. ; Tofts, Paul S. ; Tozer, Gillian M. ; van Herk, Marcel ; Walker-Samuel, Simon ; Wason, James ; Williams, Kaye J. ; Workman, Paul ; Yankeelov, Thomas E. ; Brindle, Kevin M. ; McShane, Lisa M. ; Jackson, Alan ; Waterton, John C. / Imaging biomarker roadmap for cancer studies. In: Nature Reviews Clinical Oncology. 2016.
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AU - Aboagye, Eric O.

AU - Adams, Judith E.

AU - Aerts, Hugo J W L

AU - Barrington, Sally F.

AU - Beer, Ambros J.

AU - Boellaard, Ronald

AU - Bohndiek, Sarah E.

AU - Brady, Michael

AU - Brown, Gina

AU - Buckley, David L.

AU - Chenevert, Thomas L.

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AU - Collette, Sandra

AU - Cook, Gary J.

AU - deSouza, Nandita M.

AU - Dickson, John C.

AU - Dive, Caroline

AU - Evelhoch, Jeffrey L.

AU - Faivre-Finn, Corinne

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AU - Gilbert, Fiona J.

AU - Gillies, Robert J.

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AU - Griffiths, John R.

AU - Groves, Ashley M.

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AU - Hutton, Brian F.

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AU - Jayson, Gordon C.

AU - Jones, Andrew

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AU - Lythgoe, Mark F.

AU - Manoharan, Prakash

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AU - Miles, Kenneth A.

AU - Morgan, Bruno

AU - Morris, Steve

AU - Ng, Tony

AU - Padhani, Anwar R.

AU - Parker, Geoff J M

AU - Partridge, Mike

AU - Pathak, Arvind

AU - Peet, Andrew C.

AU - Punwani, Shonit

AU - Reynolds, Andrew R.

AU - Robinson, Simon P.

AU - Shankar, Lalitha K.

AU - Sharma, Ricky A.

AU - Soloviev, Dmitry

AU - Stroobants, Sigrid

AU - Sullivan, Daniel C.

AU - Taylor, Stuart A.

AU - Tofts, Paul S.

AU - Tozer, Gillian M.

AU - van Herk, Marcel

AU - Walker-Samuel, Simon

AU - Wason, James

AU - Williams, Kaye J.

AU - Workman, Paul

AU - Yankeelov, Thomas E.

AU - Brindle, Kevin M.

AU - McShane, Lisa M.

AU - Jackson, Alan

AU - Waterton, John C.

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